• Publications
  • Influence
Cyclooxygenase-2--10 years later.
  • B. Hinz, K. Brune
  • Medicine
  • The Journal of pharmacology and experimental…
  • 1 February 2002
The enzyme cyclooxygenase (COX) catalyzes the first step of the synthesis of prostanoids. In the early 1990s, COX was demonstrated to exist as two distinct isoforms. COX-1 is constitutively expressedExpand
Acetaminophen (paracetamol) is a selective cyclooxygenase‐2 inhibitor in man
For more than three decades, acetaminophen (INN, paracetamol) has been claimed to be devoid of significant inhibition of peripheral prostanoids. Meanwhile, attempts to explain its action byExpand
Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1.
  • R. Ramer, B. Hinz
  • Biology, Medicine
  • Journal of the National Cancer Institute
  • 2 January 2008
BACKGROUND Cannabinoids, in addition to having palliative benefits in cancer therapy, have been associated with anticarcinogenic effects. Although the antiproliferative activities of cannabinoidsExpand
Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesic
Dipyrone (INN, metamizol) is a common analgesic used worldwide. Its widespread prescription or over‐the‐counter use in many countries (e.g., Brazil, Israel, Mexico, Russia, Spain) requires insightExpand
COX-2 and PPAR-γ Confer Cannabidiol-Induced Apoptosis of Human Lung Cancer Cells
The antitumorigenic mechanism of cannabidiol is still controversial. This study investigates the role of COX-2 and PPAR-γ in cannabidiol's proapoptotic and tumor-regressive action. In lung cancerExpand
The Impact of Unlicensed and Off-Label Drug Use on Adverse Drug Reactions in Paediatric Patients
AbstractBackground and objective: Many drugs that are used to treat children are either not licensed for use in paediatric patients (unlicensed) or prescribed outside the terms of the product licenceExpand
Rapid Non-Genomic Feedback Effects of Glucocorticoids on CRF-Induced ACTH Secretion in Rats
AbstractPurpose. The present study investigates fast negative feedback actions of corticosterone (corticosteroid type I/type II receptor agonist) and RU 28362 (corticosteroid type II receptorExpand
Salicylate metabolites inhibit cyclooxygenase-2-dependent prostaglandin E(2) synthesis in murine macrophages.
The poor cyclooxygenase (COX) inhibitor and major aspirin metabolite salicylic acid is known to exert analgesic and anti-inflammatory effects by still unidentified mechanisms. In RAW 264.7Expand
Decrease of Plasminogen Activator Inhibitor-1 May Contribute to the Anti-Invasive Action of Cannabidiol on Human Lung Cancer Cells
ABSTRACTPurposeUsing human lung cancer cells, we evaluated the involvement of plasminogen activator inhibitor-1 (PAI-1) in the anti-invasive action of cannabidiol, a non-psychoactiveExpand
Up-Regulation of Cyclooxygenase-2 Expression Is Involved in R(+)-Methanandamide-Induced Apoptotic Death of Human Neuroglioma Cells
Cannabinoids have been implicated in the reduction of glioma growth. The present study investigated a possible relationship between the recently shown induction of cyclooxygenase (COX)-2 expressionExpand