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tetramic acid

Known as: 1,5-dihydro-4-hydroxy-2H-pyrrol-2-one 
National Institutes of Health

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Broader (1)

Pyrrolidinones

Papers overview

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2015
2015
Discovery of a new family of Dieckmann cyclases essential to tetramic acid and pyridone-based natural products biosynthesis.
Bioinformatic analyses indicate that TrdC, SlgL, LipX2, KirHI, and FacHI belong to a group of highly homologous proteins involved… 
2013
2013
Enterococcus faecalis Inhibits Superantigen Toxic Shock Syndrome Toxin-1-Induced Interleukin-8 from Human Vaginal Epithelial Cells through Tetramic Acids
The vaginal mucosa can be colonized by many bacteria including commensal organisms and potential pathogens, such as… 
2009
2009
Cytotoxic and HLE-Inhibitory Tetramic Acid Derivatives from Marine-Derived Fungi
Tetramic acid derivatives are an important class of nitrogen heterocycles with a pyrrolidine-2,4-dione core as a key structural… 
2008
2008
Synthesis and Biological Properties of Cylindramide Derivatives: Evidence for Calcium‐Dependent Cytotoxicity of Tetramic Acid Lactams
To gain insight into the biological properties of tetramic acid lactam cylindramide 1, the analogues 4 a–d bearing a cyclopentane… 
Review
2006
Review
2006
Domino syntheses of bioactive tetronic and tetramic acids
Natural products containing tetronic acid or tetramic acid moieties continue to attract the interest of chemists, biologists, and… 
2006
2006
Melophlins P, Q, R, and S: four new tetramic acid derivatives, from two Palauan marine sponges of the genus Melophlus.
Four new tetramic acid derivatives, named melophlins P, Q, R, and S (1-4), were isolated from two marine sponges of the genus… 
2002
2002
Ravenic acid, a new tetramic acid isolated from a cultured microfungus, Penicillium sp.
A new antibiotic polyene tetramic acid, ravenic acid (2), has been isolated from the mycelia of a cultured fungus, Penicillium sp… 
1988
1988
Tirandalydigin, a novel tetramic acid of the tirandamycin-streptolydigin type. II. Isolation and structural characterization.
Tirandalydigin a structurally unique hybrid of the tirandamycin-streptolydigin families of tetramic acid antibiotics has been… 
1980
1980
C NMR spectra of streptolydigin, tirandamycin, and related degradation products.
Absorptions of the 32 carbon atoms of streptolydigin, a 3-acyltetramic acid, have been assigned in its C NMR spectrum, as have… 
1973
1973
Microbial Production of Tenuazonic Acid Analogues
The fungus Alternaria tenuis normally produces tenuazonic acid (3-acetyl-5-secbutyltetramic acid). On supplementation of the… 
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