S. Kehraus

Publications134
h-index35
Citations3,387
Highly Influential Citations131
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The experimental power of FR900359 to study Gq-regulated biological processes
TLDR
The plant-derived depsipeptide FR900359 is systematically characterize as a selective inhibitor of Gq/11/14 over all other mammalian Gα isoforms and elaborate its molecular mechanism of action.
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Decoding Signaling and Function of the Orphan G Protein–Coupled Receptor GPR17 with a Small-Molecule Agonist
TLDR
An inhibitory role for GPR17 is established in the cellular maturation process that enables remyelination of injured axons and suggest that GPR 17 may be pharmacologically targeted to treat MS.
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Antiprotozoal activities of heterocyclic-substituted xanthones from the marine-derived fungus Chaetomium sp.
Investigations of the marine-derived fungus Chaetomium sp. led to the isolation of the new natural products chaetoxanthones A, B, and C (1-3). Compounds 1 and 2 are substituted with a…
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Seasonal variation of polyphenolics in Ascophyllum nodosum (Phaeophyceae)
TLDR
Both quantitative and qualitative analysis of phlorotannins revealed variations over the course of the year, with the highest phenol content during the year was reached in July.
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Natural Products from Marine Organisms and Their Associated Microbes
TLDR
The complexity of associations in marine organisms, especially in sponges, bryozoans and tunicates, makes it extremely difficult to definitively state the biosynthetic source of many marine natural products or to deduce their ecological significance.
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Potential cancer chemopreventive in vitro activities of monomeric xanthone derivatives from the marine algicolous fungus Monodictys putredinis.
TLDR
Investigation of the fungal strain Monodictys putredinis isolated from the inner tissue of a marine green alga led to the isolation of four new monomeric xanthones and a benzophenone, which were examined for their cancer chemopreventive potential.
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Epoxyphomalin A and B, prenylated polyketides with potent cytotoxicity from the marine-derived fungus Phoma sp.
TLDR
Epoxyphomalin A showed superior cytotoxicity at nanomolar concentrations toward 12 of a panel of 36 human tumor cell lines, and in COMPARE analyses, the observed cytotoxic selectivity pattern of 1 did not correlate with those of reference anticancer agents with known mechanisms of action.
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In vitro chemopreventive potential of fucophlorethols from the brown alga Fucus vesiculosus L. by anti-oxidant activity and inhibition of selected cytochrome P450 enzymes.
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Evaluation of quantitative methods for the determination of polyphenols in algal extracts.
TLDR
Four methods for the quantitative determination of phlorotannins are compared and the determination using Folin-Ciocalteu's phenol reagent and qHNMR proved to be the most reliable and precise methods.
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Biosynthesis of the Myxobacterial Antibiotic Corallopyronin A
TLDR
The stereochemistry of corallopyronin A was deduced by a combination of a modified Mosher's method and ozonolysis with subsequent chiral GC analyses, and it was suggested that CorB is a trans‐acting ketosynthase and it is proposed that it catalyses the Claisen condensation responsible for the interconnection of the two chains.
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