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The neuropeptide Neuromedin U stimulates innate lymphoid cells and type 2 inflammation
Data indicate that the NMU–NMUR1 neuronal signalling circuit provides a selective mechanism through which the enteric nervous system and innate immune system integrate to promote rapid type 2 cytokine responses that can induce anti-microbial, inflammatory and tissue-protective type 2 responses at mucosal sites.
The experimental power of FR900359 to study Gq-regulated biological processes
The plant-derived depsipeptide FR900359 is systematically characterize as a selective inhibitor of Gq/11/14 over all other mammalian Gα isoforms and elaborate its molecular mechanism of action.
Biological activities of cyanobacteria: evaluation of extracts and pure compounds.
A total of 80 lipophilic and hydrophilic extracts obtained from 20 samples of cultured freshwater and terrestrial cyanobacteria were investigated for their biological activities. Of all the extracts,
Lack of beta-arrestin signaling in the absence of active G proteins
A state of “zero functional G” is achieved at the cellular level using HEK293 cells depleted by CRISPR/Cas9 technology of the Gs/q/12 families of Gα proteins, along with pertussis toxin-mediated inactivation of Gi/o.
Ascosalipyrrolidinone A, an antimicrobial alkaloid, from the obligate marine fungus Ascochyta salicorniae.
The endophytic and obligate marine fungus Ascochyta salicorniae was isolated and found to produce the unprecedented and structurally unusual tetramic acid containing metabolites ascosalipyrrolidinones A and B, which has antiplasmodial activity and inhibiting tyrosine kinase p56lck.
Decoding Signaling and Function of the Orphan G Protein–Coupled Receptor GPR17 with a Small-Molecule Agonist
An inhibitory role for GPR17 is established in the cellular maturation process that enables remyelination of injured axons and suggest that GPR 17 may be pharmacologically targeted to treat MS.
Secondary Metabolites of Flustra foliacea and Their Influence on Bacteria
The North Sea bryozoan Flustra foliacea was investigated to determine its secondary metabolite content and the antagonistic effect on N-acyl-homoserine lactone-dependent quorum-sensing systems was investigated.
Terpenoids from Marine Organisms: Unique Structures and their Pharmacological Potential
Despite the many structures known and their ecological and pharmacological importance, only a few biosynthetic studies on marine terpenoid compounds have been performed.
Antiprotozoal activities of heterocyclic-substituted xanthones from the marine-derived fungus Chaetomium sp.
Investigations of the marine-derived fungus Chaetomium sp. led to the isolation of the new natural products chaetoxanthones A, B, and C (1-3). Compounds 1 and 2 are substituted with a