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Inhibition of Eukaryotic Translation Elongation by Cycloheximide and Lactimidomycin
TLDR
A systematic comparative study of the effects of CHX and LTM on protein translation revealed both similarities and differences between the two inhibitors.
Minimum Information about a Biosynthetic Gene cluster.
TLDR
This work proposes the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard, to facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters.
Antitumor antibiotics: bleomycin, enediynes, and mitomycin.
TLDR
The present paper focuses on Bleomycin, a single-celled bacterium which has shown the versatility of its ability to Binding Protein and Transport Proteins, and its application in the Response to Enediyness.
Spiroindimicins A-D: new bisindole alkaloids from a deep-sea-derived actinomycete.
A PCR-based screening approach led to the identification of a deep-sea-derived Streptomyces sp. SCSIO 03032 capable of producing new bisindole alkaloids spiroindimicins A-D (1-4). Structural
Lobophorins E and F, new spirotetronate antibiotics from a South China Sea-derived Streptomyces sp. SCSIO 01127
TLDR
The strain SCSIO 01127, isolated from the South China Sea sediment, was identified as a member of Streptomyces by the 16S rDNA sequence analysis and two new spirotetronate antibiotics lobophorins E (1) and F (2) showed antibacterial activities against Staphylococcus aureus AT CC 29213 and Enterococcus faecalis ATCC 29212.
Cyclic heptapeptides, cordyheptapeptides C-E, from the marine-derived fungus Acremonium persicinum SCSIO 115 and their cytotoxic activities.
TLDR
Three new cycloheptapeptides, cordyheptAPEptides C-E (1-3), were isolated from the fermentation extract of the marine-derived fungus Acremonium persicinum SCSIO 115 and displayed cytotoxicity against SF-268, MCF-7, and NCI-H460 tumor cell lines with IC(50) values ranging from 2.5 to 12.1 μM.
Halogenated anthraquinones from the marine-derived fungus Aspergillus sp. SCSIO F063.
TLDR
Seven new chlorinated anthraquinones related to averantin are unveiled and one metabolite displayed inhibition activity against three human tumor cell lines, SF-268, MCF-7, and NCI-H460.
Antimalarial β-carboline and indolactam alkaloids from Marinactinospora thermotolerans, a deep sea isolate.
TLDR
The new compounds 1-6 were inactive against a panel of eight tumor cell lines but exhibited antiplasmodial activities against Plasmodium falciparum lines 3D7 and Dd2, with IC50 values ranging from 1.92 to 36.03 μM.
Azaphilones and p-terphenyls from the mangrove endophytic fungus Penicillium chermesinum (ZH4-E2) isolated from the South China Sea.
TLDR
Eight secondary metabolites, including three new azaphilones (chermesinones A-C, 1-3), three new p-terphenyls (6'-O-desmethylterphenyllin, 4; 3''-deoxy-6'- O-des methylterphenymethylcandidusin B, 7), and two known p-ters were isolated from the culture of the mangrove endophytic fungus Penicillium chermesinum.
Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652.
TLDR
A new sequential tristhiazole-thiazoline-containing cyclic peptide, marthiapeptide A (1), was isolated from a 60 L scale culture of the deep South China Sea-derived strain Marinactinospora thermotolerans SCSIO 00652 and displayed strong cytotoxic activity against a panel of human cancer cell lines.
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