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Pacidamycins, a novel series of antibiotics with anti-Pseudomonas aeruginosa activity. II. Isolation and structural elucidation.
A novel class of antibiotics was isolated from cultures of Streptomyces coeruleorubidus strain AB 1183F-64. The antimicrobial activity of the pacidamycins is selective against Pseudomonas aeruginosa.Expand
In vitro metabolism of the HIV-1 protease inhibitor ABT-378: species comparison and metabolite identification.
The results of the current study indicate that ABT-378 is highly susceptible to oxidative metabolism in vitro, and possibly in vivo, in humans. Expand
Calbistrins, novel antifungal agents produced by Penicillium restrictum. II. Isolation and elucidation of structure.
NMR studies revealed that the calbistrins each contain a carboxylic acid conjugated tetraene attached through an aliphatic ester linkage to a hexahydronaphthalene system. Expand
Tiacumicins, a novel complex of 18-membered macrolides. II. Isolation and structure determination.
A novel complex of Gram-positive antibiotics has been isolated from the fermentation broth and mycelium of Dactylosporangium aurantiacum subsp. hamdenesis subsp. nov. The structures of these sixExpand
New antibiotics from genetically engineered actinomycetes. I. 2-Norerythromycins, isolation and structural determinations.
The major components produced have been isolated and identified as 2-norerythromycins A, B, C and D by mass spectrometry and extensive 1D and 2D NMR experiments. Expand
Tirandalydigin, a novel tetramic acid of the tirandamycin-streptolydigin type. II. Isolation and structural characterization.
Tirandalydigin a structurally unique hybrid of the tirandamycin-streptolydigin families of tetramic acid antibiotics has been isolated from the fermentation beers of Streptomyces sp. AB-1006A-9. TheExpand
Novel macrolides via meso-tetraarylmetalloporphyrin assisted oxidations
Abstract The oxidation of Clarithromycin A with meso -tetraarylmetalloporphyrins and NaOCl led to the formation of the 3′-NClMe Clarithromycin A ( 5 ) 3′-oxo Clarithromycin ( 6 ) and Clarithromycin AExpand
Dunaimycins, a new complex of spiroketal 24-membered macrolides with immunosuppressive activity. II. Isolation and elucidation of structures.
These structures represent the first reported spiroketal 24-membered macrolide natural products related to the common 26- Membered oligomycins. Expand
Phenelfamycins, a novel complex of elfamycin-type antibiotics. II. Isolation and structure determination.
A novel complex of elfamycin-type antibiotics has been isolated from submerged fermentation of either Streptomyces violaceoniger AB 999F-80 or Streptococcal AB 1047T-33 using a variety of spectroscopic techniques, including extensive use of 1D and 2D NMR spectroscopy. Expand
2,3-Diaminophenazine is the product from the horseradish peroxidase-catalyzed oxidation of o-phenylenediamine.
NMR and mass spectroscopic evidence has been obtained which indicates that the product of the oxidation of o-phenylenediamine by hydrogen peroxide, uncatalyzed or catalyzed by horseradish peroxidase,Expand