• Publications
  • Influence
Calbistrins, novel antifungal agents produced by Penicillium restrictum. II. Isolation and elucidation of structure.
TLDR
NMR studies revealed that the calbistrins each contain a carboxylic acid conjugated tetraene attached through an aliphatic ester linkage to a hexahydronaphthalene system. Expand
Tirandalydigin, a novel tetramic acid of the tirandamycin-streptolydigin type. II. Isolation and structural characterization.
Tirandalydigin a structurally unique hybrid of the tirandamycin-streptolydigin families of tetramic acid antibiotics has been isolated from the fermentation beers of Streptomyces sp. AB-1006A-9. TheExpand
Normal phase and reverse phase HPLC-UV-MS analysis of process impurities for rapamycin analog ABT-578: application to active pharmaceutical ingredient process development.
TLDR
Process control strategies were established with these combinations of analytical technologies for impurities analyses to enable a rich understanding of the ABT-578 process. Expand
Novel Triterpene Sulfates from Fusarium compactum Using a Rhinovirus 3C Protease Inhibitor Screen.
© Japan Antibiotics Research Association Two novel triterpene sulfates have been isolated from Fusarium compactum by bioactivitydirected fractionation using an assay which measures the inhibition ofExpand
Use of Coil Planet Centrifuge in the Isolation of Antibiotics
Abstract In the course of isolating antibiotics from actinomycete fermentations, we have found the Ito Multi-Layer Coil Planet Centrifuge (CPC) can effect separations of such quality on crudeExpand
Dunaimycins, a new complex of spiroketal 24-membered macrolides with immunosuppressive activity. II. Isolation and elucidation of structures.
TLDR
These structures represent the first reported spiroketal 24-membered macrolide natural products related to the common 26- Membered oligomycins. Expand
Arizonins, a new complex of antibiotics related to kalafungin. II. Isolation and characterization.
A new complex of anti-Gram-positive antibiotics was produced by the fermentation of Actinoplanes arizonaensis sp. nov. The antibiotics were recovered from the fermentation broth with Amberlite XAD-7Expand
Altromycins, novel pluramycin-like antibiotics. II. Isolation and elucidation of structure.
TLDR
A novel complex of Gram-positive antibiotics was produced from the fermentation of an actinomycete culture AB 1246E-26, indicating a new complex of compounds related to, but distinctly different from the pluramycin type antibiotics. Expand
Novel triterpene sulfates from Fusarium compactum using a rhinovirus 3C protease inhibitor screen.
Two novel triterpene sulfates have been isolated from Fusarium compactum by bioactivity-directed fractionation using an assay which measures the inhibition of proteolytic activity of rhinovirus 3CExpand
Dibefurin, a novel fungal metabolite inhibiting calcineurin phosphatase activity.
The novel calcineurin inhibitor, dibefurin, has been isolated from the fungal culture AB 1650I-759. The isolation was bioactivity-directed fractionation using an assay which measures the phosphataseExpand
...
1
2
...