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tetracenomycin

Known as: 1,4,4a,5,12,12a-hexahydro-4,4a,11,12a-tetrahydroxy-3,8-dimethoxy-9-methoxycarbonyl-10-methyl-1,5,12-trioxonaphthacene 
 
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Polyketides are a class of natural products with highly diverse chemical structures and pharmaceutical activities. Polyketide… Expand
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Highly Cited
2007
Highly Cited
2007
Iterative fungal polyketide synthases (PKSs) use a unique set of biochemical rules in the synthesis of complex polyketides. These… Expand
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Highly Cited
2005
Highly Cited
2005
Cultivation of the marine-derived streptomycete isolate B8005 delivered three known antibiotics, resistomycin (1), resistoflavin… Expand
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Highly Cited
2004
Highly Cited
2004
Sugar biosynthesis cassette genes have been used to construct plasmids directing the biosynthesis of branched-chain deoxysugars… Expand
Highly Cited
1998
Highly Cited
1998
The tetracenomycin polyketide synthase (TCM PKS), a type II complex, produces TCM F2, a precursor of TCM C in Streptomyces… Expand
Highly Cited
1997
Highly Cited
1997
The oxidation of phenols to quinones is an important reaction in the oxidative tailoring of many aromatic polyketides from… Expand
Highly Cited
1995
Highly Cited
1995
Streptomyces glaucescens, a Gram-positive soil bacterium, produces the polyketide antibiotic tetracenomycin (Tcm) C. To study… Expand
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1994
1994
The development of microorganisms with improved antibiotic production is an important goal in the commercialization of new… Expand
Highly Cited
1993
Highly Cited
1993
The gene that encodes the acyl carrier protein (ACP) of the actinorhodin polyketide synthase (PKS) of Streptomyces coelicolor A3… Expand
Highly Cited
1993
Highly Cited
1993
Microorganisms and plants manufacture a large collection of medically and commercially useful natural products called polyketides… Expand