Tomoka Maruta

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The angucycline antibiotics1,2 are characterized by containing the modified benz[a]anthraquinone chromophore and show antimicrobial, antitumor and/or enzyme-inhibitory activities. Streptomyces sp. 2238-SVT4 produced four angucyclines, hatomarubigins A, B, C and D (Figure 1a), which enhanced the cytotoxicity of colchicine in multidrug-resistant tumor cells.3(More)
Streptomyces sp. strain 2238-SVT4 produces hatomarubigins A, B, C, and D, which belong to the angucycline family. Among them, hatomarubigin D has a unique dimeric structure with a methylene linkage. PCR using aromatase and cyclase gene-specific primers identified the hrb gene cluster for angucycline biosynthesis in Streptomyces sp. 2238-SVT4. The cluster(More)
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