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An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190.
- K. Kaneda, T. Kuzuyama, M. Takagi, Y. Hayakawa, H. Seto
- BiologyProceedings of the National Academy of Sciences…
- 30 January 2001
The results indicate that orfD encodes an unusual IPP isomerase showing no sequence similarity to those of IPp isomerases identified to date, considered to be a suitable molecular target for the screening of antibacterial drugs specific to S. aureus.
Effect on tumor cells of blocking survival response to glucose deprivation.
- Hae‐Ryong Park, A. Tomida, K. Shin‐ya
- Biology, MedicineJournal of the National Cancer Institute
- 1 September 2004
The UPR-inhibitory action of VST was seen only in conditions of glucose deprivation and caused selective and massive killing of the glucose-deprived cells.
Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus.
Cloning and Heterologous Expression of the Thioviridamide Biosynthesis Gene Cluster from Streptomyces olivoviridis
- M. Izawa, T. Kawasaki, Y. Hayakawa
- Biology, EngineeringApplied and Environmental Microbiology
- 30 August 2013
Thioviridamide is a unique peptide antibiotic containing five thioamide bonds from Streptomyces olivoviridis and a gene (the tvaA gene) encoding the thiovirinamide precursor peptide was identified by heterologous production of thiovIRidamide in StrePTomyces lividans.
Insect Cytokine Growth-blocking Peptide Triggers a Termination System of Cellular Immunity by Inducing Its Binding Protein*
It is proposed that insect cytokine GBP shows multifunctions even in cellular immunity: it serves to stimulate immune cells and afterward silences its own action by inducing the binding protein through specific hemolysis.
Cell growth activity of growth-blocking peptide.
Bioassay data and in vivo studies suggest that GBP acts as a growth factor that regulates insect larval development and shares some structural similarities with human epidermal growth factors.
Thioviridamide, a Novel Apoptosis Inducer in Transformed Cells from Streptomyces olivoviridis
- Y. Hayakawa, Kahori Sasaki, H. Adachi, K. Furihata, K. Nagai, K. Shin‐ya
- Biology, ChemistryThe Journal of Antibiotics
Thioviridamide showed cytotoxicity selectively against 3Y1 rat fibroblasts transformed with adenovirus oncogenes and significant numbers of Ad12-3Y1 cells treated with thiovirIDamide contained condensed chromatin and fragmented nuclei, indicating that thiovIRidamide induced apoptosis.
Versipelostatin, a novel GRP78/Bip molecular chaperone down-regulator of microbial origin
Dopamine is a key factor for the induction of egg diapause of the silkworm, Bombyx mori.
Data indicate that environmental stimuli during embryonic development increase dopamine levels in both hemolymph and Br-SGs from the larval stage to early pupal stage, which results in laying of diapause-destined eggs by female adults through enhanced expression of the diAPause hormone gene.