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An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190.
The results indicate that orfD encodes an unusual IPP isomerase showing no sequence similarity to those of IPp isomerases identified to date, considered to be a suitable molecular target for the screening of antibacterial drugs specific to S. aureus.
Effect on tumor cells of blocking survival response to glucose deprivation.
The UPR-inhibitory action of VST was seen only in conditions of glucose deprivation and caused selective and massive killing of the glucose-deprived cells.
Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus.
Cloning and Heterologous Expression of the Thioviridamide Biosynthesis Gene Cluster from Streptomyces olivoviridis
Thioviridamide is a unique peptide antibiotic containing five thioamide bonds from Streptomyces olivoviridis and a gene (the tvaA gene) encoding the thiovirinamide precursor peptide was identified by heterologous production of thiovIRidamide in StrePTomyces lividans.
Insect Cytokine Growth-blocking Peptide Triggers a Termination System of Cellular Immunity by Inducing Its Binding Protein*
It is proposed that insect cytokine GBP shows multifunctions even in cellular immunity: it serves to stimulate immune cells and afterward silences its own action by inducing the binding protein through specific hemolysis.
Cell growth activity of growth-blocking peptide.
Bioassay data and in vivo studies suggest that GBP acts as a growth factor that regulates insect larval development and shares some structural similarities with human epidermal growth factors.
Thioviridamide, a Novel Apoptosis Inducer in Transformed Cells from Streptomyces olivoviridis
Thioviridamide showed cytotoxicity selectively against 3Y1 rat fibroblasts transformed with adenovirus oncogenes and significant numbers of Ad12-3Y1 cells treated with thiovirIDamide contained condensed chromatin and fragmented nuclei, indicating that thiovIRidamide induced apoptosis.
Dopamine is a key factor for the induction of egg diapause of the silkworm, Bombyx mori.
Data indicate that environmental stimuli during embryonic development increase dopamine levels in both hemolymph and Br-SGs from the larval stage to early pupal stage, which results in laying of diapause-destined eggs by female adults through enhanced expression of the diAPause hormone gene.