An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190.
- K. Kaneda, T. Kuzuyama, M. Takagi, Y. Hayakawa, H. Seto
- BiologyProceedings of the National Academy of Sciences…
- 30 January 2001
The results indicate that orfD encodes an unusual IPP isomerase showing no sequence similarity to those of IPp isomerases identified to date, considered to be a suitable molecular target for the screening of antibacterial drugs specific to S. aureus.
Effect on tumor cells of blocking survival response to glucose deprivation.
- Hae‐Ryong Park, A. Tomida, K. Shin‐ya
- Biology, MedicineJournal of the National Cancer Institute
- 1 September 2004
The UPR-inhibitory action of VST was seen only in conditions of glucose deprivation and caused selective and massive killing of the glucose-deprived cells.
Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus.
- K. Shin‐ya, K. Wierzba, H. Seto
- BiologyJournal of the American Chemical Society
- 20 January 2001
Piericidins C7 and C8, New Cytotoxic Antibiotics Produced by a Marine Streptomyces sp.
- Y. Hayakawa, Shingo Shirasaki, Y. Shizuri
- Biology, ChemistryJournal of antibiotics (Tokyo. )
- 1 March 2007
Piericidins C7 and C8 showed selective cytotoxicity against rat glia cells transformed with the adenovirus E1A gene and Neuro-2a mouse neuroblastoma cells (IC50 C7): 0.83 nM, C8: 0.21 nM).
Insect Cytokine Growth-blocking Peptide Triggers a Termination System of Cellular Immunity by Inducing Its Binding Protein*
- Y. Matsumoto, Y. Oda, M. Uryu, Y. Hayakawa
- BiologyJournal of Biological Chemistry
- 3 October 2003
It is proposed that insect cytokine GBP shows multifunctions even in cellular immunity: it serves to stimulate immune cells and afterward silences its own action by inducing the binding protein through specific hemolysis.
Cloning and Heterologous Expression of the Thioviridamide Biosynthesis Gene Cluster from Streptomyces olivoviridis
- M. Izawa, T. Kawasaki, Y. Hayakawa
- Biology, EngineeringApplied and Environmental Microbiology
- 30 August 2013
Thioviridamide is a unique peptide antibiotic containing five thioamide bonds from Streptomyces olivoviridis and a gene (the tvaA gene) encoding the thiovirinamide precursor peptide was identified by heterologous production of thiovIRidamide in StrePTomyces lividans.
Cell growth activity of growth-blocking peptide.
- Y. Hayakawa, A. Ohnishi
- BiologyBiochemical and Biophysical Research…
- 18 September 1998
Bioassay data and in vivo studies suggest that GBP acts as a growth factor that regulates insect larval development and shares some structural similarities with human epidermal growth factors.
Thioviridamide, a Novel Apoptosis Inducer in Transformed Cells from Streptomyces olivoviridis
- Y. Hayakawa, Kahori Sasaki, H. Adachi, K. Furihata, K. Nagai, K. Shin‐ya
- Biology, ChemistryJournal of antibiotics (Tokyo. )
- 2006
Thioviridamide showed cytotoxicity selectively against 3Y1 rat fibroblasts transformed with adenovirus oncogenes and significant numbers of Ad12-3Y1 cells treated with thiovirIDamide contained condensed chromatin and fragmented nuclei, indicating that thiovIRidamide induced apoptosis.
Versipelostatin, a novel GRP78/Bip molecular chaperone down-regulator of microbial origin
- Hae‐Ryong Park, K. Furihata, Y. Hayakawa, K. Shin‐ya
- Chemistry, Biology
- 23 September 2002
Isolation and structural elucidation of an antioxidative agent, naphterpin.
- K. Shin‐ya, S. Imai, H. Seto
- BiologyJournal of antibiotics (Tokyo. )
- 25 April 1990
The fermentation, isolation and structure determination of naphterpin are reported, which succeeded in isolating a new antioxidative agent, named naph terpin, from Ishigaki Island, Okinawa Prefecture, Japan.
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