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Effect on tumor cells of blocking survival response to glucose deprivation.
BACKGROUND Glucose deprivation, a feature of poorly vascularized solid tumors, activates the unfolded protein response (UPR), a stress-signaling pathway, in tumor cells. We recently isolated a novelExpand
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Versipelostatin, a novel GRP78/Bip molecular chaperone down-regulator of microbial origin
Abstract We discovered a novel down-regulator of grp78 gene expression designated as versipelostatin from the culture broth of Streptomyces versipellis 4083-SVS6. Its structure was determined to be aExpand
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Wound-induced ethylene synthesis and expression and formation of 1-aminocyclopropane-1-carboxylate (ACC) synthase, ACC oxidase, phenylalanine ammonia-lyase, and peroxidase in wounded mesocarp tissue
1-Aminocyclopropane-1-carboxylate (ACC) synthase was rapidly induced in mesocarp tissue of Cucurbita maxima after wounding in the cut surface layer in 1 mm thickness (ca. 9 cells) (first layer) inExpand
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Cloning and Heterologous Expression of the Thioviridamide Biosynthesis Gene Cluster from Streptomyces olivoviridis
ABSTRACT Thioviridamide is a unique peptide antibiotic containing five thioamide bonds from Streptomyces olivoviridis. Draft genome sequencing revealed a gene (the tvaA gene) encoding theExpand
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A prodigiosin from the roseophilin producer Streptomyces griseoviridis.
Roseophilin is a unique metabolite containing two pyrrole and one furan ring and is structurally related to tripyrrole antibiotics, prodigiosins. Each homologous gene in the roseophilin producerExpand
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Efrapeptin J, a New Down-regulator of the Molecular Chaperone GRP78 from a Marine Tolypocladium sp.
A new down-regulator of the molecular chaperone GRP78, efrapeptin J, was isolated from a marine fungus, Tolypocladium sp. AMB18. The molecular formula of efrapeptin J was established asExpand
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Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp.
Nocardiopsis sp. was found to produce a new active compound designated apoptolidin (Fig. 1). In this report, we describe the production, isolation, physico-chemical properties and biological activityExpand
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Factors influencing cyclic AMP and diacylglycerol levels in fat body of Locusta migratoria
Abstract Forskolin (FORSK), octopamine (OA) and adipokinetic hormone (AKH) stimulate the production of diacylglycerol (DG) in fat body of the locust, Locusta migratoria and the release of DG from fatExpand
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Isolation and structural elucidation of an antioxidative agent, naphterpin.
Active oxygen species cause a variety of diseases such as inflammation, autoimmune disease, diabetes, rheumatism, cardiovascular diseases and cancer-initiation1>2). Thus, it could be expected thatExpand
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Structure-antitumor activity relationship of semi-synthetic spicamycin analogues.
Spicamycin, a nucleoside antibiotic containing fatty acids with a variety of chain lengths (C12-C18), showed potent antitumor activity against human gastric cancer SC-9 and human breast cancer MX-1Expand
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