• Publications
  • Influence
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
The 8,667,507 base pair linear chromosome of Streptomyces coelicolor is reported, containing the largest number of genes so far discovered in a bacterium. Expand
A set of ordered cosmids and a detailed genetic and physical map for the 8 Mb Streptomyces coelicolor A3(2) chromosome
A Supercos‐1 library carrying chromosomal DNA of a plasmid‐free derivative of Streptomyces coelicolor A3(2) was organized into an ordered encyclopaedia of overlapping clones by hybridization, finding that the ends of the chromosome have long terminal inverted repeats. Expand
Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces
This work proposes the first complete signalling cascade from nutrient sensing to development and antibiotic biosynthesis, and shows that a high concentration of N‐acetylglucosamine is a major checkpoint for the onset of secondary metabolism. Expand
Practical Streptomyces Genetics: A Laboratory Manual
Novel genetic tools for diaminopimelic acid selection in virulence studies of Practical Streptomyces genetics and the genetic and proteomics of this system have not been fully studied. Expand
Genetic Contributions to Understanding Polyketide Synthases.
  • D. Hopwood
  • Chemistry, Medicine
  • Chemical reviews
  • 10 November 1997
Plasmids, recombination and chromosome mapping in Streptomyces lividans 66.
A linkage map of the S. lividans chromosome containing ten markers was derived from the results of matings using several different sex plasmids, and protoplast fusions, to study a range of Streptomyces plasmid ability to promote their own transfer and to mobilize chromosomal markers. Expand
Genetic manipulation in Streptomyces
Transfert genetique par les plasmides et les liposomes d'in conclusion de fusion de protoplastes enregistrement de clonage et vecteurs deClonage. Expand
The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of streptomyces
It is concluded that initiation of actinorhodin synthesis via the actII-ORF4 product, and the final step in production, antibiotic export, are twin targets via which bldA exerts developmental control of actarhodin production. Expand
Molecular genetics of polyketides and its comparison to fatty acid biosynthesis.
The structure of the biotechnology of POL YKETIDE SYNTHESIS is studied to understand the role of polyketides in plant growth and their role in the environment. Expand