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Our experiments were conducted to determine whether substance P (SP) would elicit an itch sensation mediated by mast cells in… Expand There is increasing evidence that neuropeptides may be involved in the pathogenesis of atopic dermatitis (AD). This study… Expand The agonist-occupied forms of several G-protein-coupled receptors that modulate the activity of adenylycyclase via Gs (e.g. beta… Expand A capsaicin test involving peripheral nociception, which produces behaviour similar to that elicited by formalin, is described in… Expand CP-96,345 has been identified as being a highly selective, nonpeptidic agent with subnanomolar affinity for the NK1 receptor. In… Expand 1 The pharmacological profile of a tachykinin antagonist, [d‐Arg1, d‐Trp7,9, Leu11] substance P (spantide), was studied on… Expand Electrical stimulus intensity, capsaicin, excitatory amino acid antagonists and the substance P antagonist, spantide, have been… Expand The neural effect of endothelin, a vasoconstrictor peptide from vascular endothelium, was investigated in the in vitro spinal… Expand The present study was undertaken to investigate the possible effects of Spantide [D-Arg1, D-Trp7,9 Leu11]-substance P, a… Expand Clonidine has been reported to produce analgesia in man after epidural and intrathecal administration. In the present… Expand