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The capsaicin test in mice for evaluating tachykinin antagonists in the spinal cord
A capsaicin test involving peripheral nociception, which produces behaviour similar to that elicited by formalin, is described in mice and may allow discrimination between SP- and SOM-mediated responses in the spinal cord of the mouse. Expand
Involvement of peripheral cannabinoid and opioid receptors in β‐caryophyllene‐induced antinociception
The contribution of peripheral cannabinoid (CB) and opioid systems in the antinociception produced by intraplantar (i.pl.) injection of BCP is investigated. Expand
Enhanced antinociception by intracerebroventricularly and intrathecally-administered orexin A and B (hypocretin-1 and -2) in mice
The present findings suggest that orexins have an antinociceptive role in at least four different types of pains, probably acting on both the brain and spinal cord. Expand
Antinociception induced by CP 96,345, a non-peptide NK-1 receptor antagonist, in the mouse formalin and capsaicin tests
CP 96,345 is antinociceptive in the capsaicin test at doses showing no overt behavioural effects but there is an overlap in doses producing antinOCiceptive and motor effects in the formalin test. Expand
Differential antagonism of endomorphin-1 and endomorphin-2 spinal antinociception by naloxonazine and 3-methoxynaltrexone
The present results suggest that endomorphin-1 and endomorphicin-2 may produce antinociception through different subtypes of mu-opioid receptor through different types of receptors in spinal sites. Expand
Neuropharmacology of the essential oil of bergamot.
The data yielded so far contribute to the understanding of the mode of action of this phytocomplex on nerve tissue under normal and pathological experimental conditions and provide a rational basis for the practical use of BEO in complementary medicine. Expand
Differential antinociceptive effects induced by intrathecally administered endomorphin-1 and endomorphin-2 in the mouse.
The results indicate that endomorphin-2 given i.t.) produces its antinociceptive effects via the stimulation of mu (1)-opioid receptors (naloxonazine-sensitive site) in the spinal cord through the stimulated release of dynorphin A and [Met(5)]enkephalin. Expand
Differential involvement of mu-opioid receptor subtypes in endomorphin-1- and -2-induced antinociception.
The results indicate that endomorphins may produce antinociception through the distinct mu1 and mu2 subtypes of mu-opioid receptor. Expand
Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice
We have previously shown that antinociceptive effects of morphine are enhanced in histamine H1 receptor gene knockout mice. In the present study, involvement of supraspinal histamine H2 receptor inExpand
Major metabolites of substance P degraded by spinal synaptic membranes antagonize the behavioral response to substance P in rats.
The results suggest that the degradation of SP in the spinal cord is not only responsible for inactivation of parent peptide, but may also lead to the formation of N-terminal SP-fragments which are shown to display a novel physiological function. Expand