• Publications
  • Influence
Neurobiology in primary headaches
TLDR
There is a clear association between the head pain and the release of the neuropeptide calcitonin gene-related peptide (CGRP) from the trigeminovascular system, and a central role for sensory and parasympathetic mechanisms in the pathophysiology of primary headaches. Expand
Calcitonin gene-related peptide: functional role in cerebrovascular regulation.
TLDR
The cerebrovascular trigeminal neuronal system, in which CGRP is the most potent vasoactive constituent, may participate in a reflex or local response to excessive cerebral vasoconstriction that restores normal vascular diameter. Expand
Pituitary adenylate cyclase activating peptide is a sensory neuropeptide: Immunocytochemical and immunochemical evidence
TLDR
The data favour a role for PACAP in primary sensory neurons in the sensory nervous system of the rat, and the immunocytochemical results agreed with those obtained by radioimmunoassay forPACAP and CGRP. Expand
Neuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibers
TLDR
Neuropeptide Y greatly enhanced the adrenergically mediate contractile response to electrical stimulation and to application of adrenaline, noradrenaline or histamine, as studied in the isolated rabbit gastro-epiploic and femoral arteries. Expand
PACAP, a VIP-like Peptide: Immunohistochemical Localization and Effect upon Cat Pial Arteries and Cerebral Blood Flow
TLDR
Double immunostaining revealed that PACAP-immunoreactive nerve fibers constituted a sub-population of the VIP-containing fibers and effected a concentration-dependent relaxation of feline middle cerebral arteries that had been precontracted with prostaglandin F2α. Expand
An assay to evaluate the long‐term effects of inflammatory mediators on murine airway smooth muscle: evidence that TNFα up‐regulates 5‐HT2A‐mediated contraction
TLDR
The time‐dependent effect of TNFα indicates the importance of studying the long‐term effect of cytokines on the smooth muscle cells in relation to airway hyperresponsiveness and remodelling. Expand
Neuropeptide Localization in the ‘Migraine Generator’ Region of the Human Brainstem
TLDR
Analysis of brainstem nuclei for the occurrence and distribution of calcitonin gene-related peptide, substance P (SP), pituitary adenylate-cyclase activating peptide (PACAP) and vasoactive intestinal polypeptide (VIP) revealed that all VMAT-and C-PON-containing neurones, in addition, stored CGRP. Expand
Messenger molecules and receptor mRNA in the human trigeminal ganglion.
TLDR
Both sympathetic and parasympathetic influence on the activity in the trigeminal ganglion are suggested, as well as the presence of mRNA corresponding to CGRP1, NPY Y2, and VIP1 receptors. Expand
Calcitonin Gene-Related Peptide and Cerebral Blood Vessels: Distribution and Vasomotor Effects
TLDR
Cardiovascular nerve fibers containing CGRP appear to be present in all mammalian species (although to varying degrees) and C GRP is invariably a potent dilator of the cerebral arteries for all species. Expand
Calcitonin gene-related peptide and nitric oxide in the trigeminal ganglion: cerebral vasodilatation from trigeminal nerve stimulation involves mainly calcitonin gene-related peptide.
TLDR
Data suggest that although NOS is seen in several trigeminal ganglion cells and coexists with CGRP in a subpopulation of the sensory neurons, its role in trigeminally mediated vasodilatation was not significant. Expand
...
1
2
3
4
5
...