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Behavioural phenotyping assays for mouse models of autism
TLDR
Robust phenotypes in mouse models hold great promise as translational tools for discovering effective treatments for components of autism spectrum disorders. Expand
Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies
TLDR
Strain distributions are described for open field activity, learning and memory tasks, aggression, sexual and parental behaviors, acoustic startle and prepulse inhibition, and the behavioral actions of ethanol, nicotine, cocaine, opiates, antipsychotics, and anxiolytics. Expand
Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia
TLDR
Atm-disrupted mice recapitulate the ataxia telangiectasia phenotype in humans, providing a mammalian model in which to study the pathophysiology of this pleiotropic disorder. Expand
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice
TLDR
A new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism. Expand
Mouse behavioral tasks relevant to autism: Phenotypes of 10 inbred strains
TLDR
A multitask strategy for modeling symptoms of autism will be useful for investigating targeted and random gene mutations, QTLs, and microarray analyses. Expand
Autistic-like behavior and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice
TLDR
It is shown that both heterozygous and homozygous loss of Tsc1 in mouse cerebellar PCs results in autistic-like behaviours, including abnormal social interaction, repetitive behaviour and vocalizations, in addition to decreased PC excitability. Expand
Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines
TLDR
The increased exploratory activity with benzodiazepines does not appear to be a non-specific increase in general motor activity, as locomotion in clonazepam and chlordiazepoxide treated mice placed in a bare, undifferentiated cage was not significantly different from vehicle treated mice. Expand
Autism‐like behavioral phenotypes in BTBR T+tf/J mice
TLDR
Robust and selective social deficits, repetitive self‐grooming, genetic stability and commercial availability of the BTBR inbred strain encourage its use as a research tool to search for background genes relevant to the etiology of autism, and to explore therapeutics to treat the core symptoms. Expand
Unusual Repertoire of Vocalizations in the BTBR T+tf/J Mouse Model of Autism
TLDR
Overall, the findings demonstrate strain-specific patterns of ultrasonic calls that may represent different lexicons, or innate variations in complex vocal repertoires, in genetically distinct strains of mice. Expand
Mouse models of Tay–Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism
TLDR
The Tay–Sachs and Sandhoff diseases are clinically similar neurodegenerative disorders and through disruption of the Hexa and Hexb genes in embryonic stem cells, mouse models corresponding to each disease are established. Expand
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