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Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation
  • F. Lembeck, P. Holzer
  • Chemistry, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • 1 December 1979
Summary1.Antidromic vasodilation and neurogenic plasma extravasation were induced by antidromic stimulation of the saphenous nerve in guanethidine-treated rats. Vasodilation was measured by theExpand
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Absorption and metabolism of capsaicinoids following intragastric administration in rats
SummaryThis study was performed to examine the metabolism and absorption of intragastrically administered capsaicinoids in the anaesthetized rat.[3H]-dihydrocapsaicin ([3H]-DHC) and unlabelledExpand
  • 78
  • 6
Analysis of the effects of intravenously injected capsaicin in the rat
Summary1.I.v. injection of 1 or 3 μg capsaicin led to a triphasic blood pressure response in Sprague-Dawley rats but, in contrast to Wistar rats, did not affect heart rate and respiration. The bloodExpand
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DECREASE OF SUBSTANCE P IN PRIMARY AFFERENT NEURONES AND IMPAIRMENT OF NEUROGENIC PLASMA EXTRAVASATION BY CAPSAICIN
1 Rats were pretreated with capsaicin (50 mg/kg, s.c.) on the 2nd, 10th, or 20th day of life. Three months later immunoreactive substance P (I‐SP) was determined in skin, sensory nerves and theExpand
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New, long‐acting, potent bradykinin antagonists
1 Three new bradykinin (BK) antagonists, d‐Arg0‐Hyp3‐Thi5‐d‐Tic7‐Oic8‐BK (compound I), d‐Arg0‐Hyp3‐d‐Tic7‐Oic8‐BK (compound II), and Arg(Tos)1‐Hyp3‐Thi5‐d‐Tic7‐Oic8‐BK (compound III), were testedExpand
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Capsaicin applied to peripheral nerve inhibits axoplasmic transport of substance P and somatostatin
Capsaicin was applied locally to the sciatic or saphenous nerve, and the effects on axoplasmic transport, neurogenic plasma extravasation, and thermal pain were studied. Capsaicin (10 mg/ml) led to aExpand
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Distribution of capsaicin in rat tissues after systemic administration
The pharmacology of capsaicin (rrans-8-methyl-N-vanillyl6-nonenamide) was reviewed by Porszisz et al (1955), Szolcsanyi (1977) and Virus & Gebhart (1979). Recent interest in capsaicin arose from itsExpand
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Inhibition of neurogenic vasodilation and plasma extravasation by substance P antagonists, somatostatin and [D-Met2, Pro5]enkephalinamide.
The substance P (SP) analogues [D-Pro2, D-Phe7, D-Trp9]SP and [D-Pro2, D-Trp7,9]SP, which have been reported to be SP antagonists, inhibited the vasodilation and plasma extravasation induced byExpand
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Effects of capsaicin on inflammation and on the substance P content of nervous tissues in rats with adjuvant arthritis.
Capsaicin (20-80 mg/kg, s.c.) reduced the inflammatory response to inoculation with Mycobacterium butyricum in the rat. The effect was apparent within 24 h, was partial, persisted for well over 20Expand
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Requirement of nerve growth factor for development of substance P-containing sensory neurones
The protein nerve growth factor (NGF) is known to be essential for the maturation and maintenance of adrenergic neurones1 and for the development of sensory neurones during critical stages ofExpand
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