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Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion
The risk genotype of MTNR1B was associated with impairment of early insulin response to both oral and intravenous glucose and with faster deterioration of insulin secretion over time, suggesting that the circulating hormone melatonin is involved in the pathogenesis of T2D. Expand
Endocrine cells in human intestine: an immunocytochemical study.
The regional and topographic distribution of endocrine cells in the human intestine was examined by immunohistochemistry and cells displaying beta-endorphin, pro-gamma-melanocyte-stimulating hormone, or beta-lipotropin immunoreactivity, or a combination of these, were found in the small intestine. Expand
The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas
Ghrelin is expressed in a quite prominent endocrine cell population in human fetal pancreas, and ghrelin expression in the Pancreas precedes by far that in the stomach. Expand
Distribution of pancreatic polypeptide and peptide YY
The cellular distribution of PP and PYY in mammals is reviewed. Expression of PP is restricted to endocrine cells mainly present in the pancreas predominantly in the duodenal portion (head) but alsoExpand
In vivo restitution of airway epithelium
It is concluded that reproducible shedding-like denudation, without bleeding or damage to the basement membrane, can be produced in vivo and rapid restitution of airway epithelium may depend on contributions from the microcirculation and innervation. Expand
Pituitary adenylate cyclase activating peptide is a sensory neuropeptide: Immunocytochemical and immunochemical evidence
The data favour a role for PACAP in primary sensory neurons in the sensory nervous system of the rat, and the immunocytochemical results agreed with those obtained by radioimmunoassay forPACAP and CGRP. Expand
Vascular endothelial growth factor is a neurotrophic factor which stimulates axonal outgrowth through the flk‐1 receptor
The results strongly suggest that VEGF acts as a neurotrophic factor and plays an important role during the regeneration of peripheral nerves. Expand
Neuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibers
Neuropeptide Y greatly enhanced the adrenergically mediate contractile response to electrical stimulation and to application of adrenaline, noradrenaline or histamine, as studied in the isolated rabbit gastro-epiploic and femoral arteries. Expand
Cocaine‐ and amphetamine‐regulated transcript: distribution and function in rat gastrointestinal tract
Although CART does not seem to play a pivotal role in classic neurotransmission to the longitudinal muscle, it may serve a modulatory role in NO transmission and be involved in intestinal adaptation, and an additional hormonal role is also possible. Expand
The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient beta-cell mass and exocytosis.
Diabetes in R6/2 mice is caused by a combination of deficient beta-cell mass and disrupted exocytosis, which could be attributed to a 96% reduction in the number of insulin-containing secretory vesicles. Expand