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Substance P

Known as: Euler Gaddum Substance P, neurokinin 1, Substance P, Euler-Gaddum 
An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes… 
National Institutes of Health

Related topics

Related topics

37 relations

Narrower (20)

Bolton Hunter reagent-substance P conjugateGR 71251GR 73632Hypothalamic Substance P
In BloodProcess of secretionSubstance P ReceptorSubstance P:MCnc:Pt:CSF:Qn

Broader (5)

NeuroregulatorsNeurotransmitter AgentsNeurotransmittersPeptides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1993
Highly Cited
1993
Substance P selectively activates TNF-alpha gene expression in murine mast cells.
There is increasing evidence that the neurologic system is capable of modulating a wide range of immunologic responses, including… 
Highly Cited
1991
Highly Cited
1991
A potent nonpeptide antagonist of the substance P (NK1) receptor.
CP-96,345 [(2S, 3S)-cis-2-(diphenylmethyl)-N-[(2-methoxyphenyl)- methyl]-1-azabicyclo[2.2.2]octan-3-amine] is a potent nonpeptide… 
Highly Cited
1991
Highly Cited
1991
Striatal Restricted Adenosine A2 Receptor (RDC8) Is Expressed by Enkephalin but Not by Substance P Neurons: An In Situ Hybridization Histochemistry Study
RDC8 has been recently cloned and characterized as an adenosine A2 receptor. This receptor is expressed exclusively by medium… 
Highly Cited
1989
Highly Cited
1989
CNS cell groups regulating the sympathetic outflow to adrenal gland as revealed by transneuronal cell body labelling with pseudorabies virus
Highly Cited
1987
Highly Cited
1987
cDNA eloping of bovine substance-K receptor through oocyte expression system
The neuropeptide receptors which are present in very small quantities in the cell and are embedded tightly in the plasma membrane… 
Highly Cited
1987
Highly Cited
1987
Release of substance P from the cat spinal cord.
1. The present experiments examine the physiology and pharmacology of the release of substance P‐like immunoreactivity (SP‐l.i… 
Highly Cited
1979
Highly Cited
1979
The origin, distribution and synaptic relationships of substance P axons in rat spinal cord
Substance P positive (SP+) immunoperoxidase reaction product has been localized in light and electron microscopic preparations of… 
Highly Cited
1978
Highly Cited
1978
Distribution of substance P-like immunoreactivity in the central nervous system of the rat—I. Cell bodies and nerve terminals
Highly Cited
1978
Highly Cited
1978
Flare and itch induced by substance P in human skin.
Intradermal injection of synthetic substance P (10(-7)--10(-5) M in humans produced flare, wheal and itching. These responses… 
Highly Cited
1975
Highly Cited
1975
Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons
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