Comparison of pharmacological activities of buprenorphine and norbuprenorphine: norbuprenorphine is a potent opioid agonist.
- P. Huang, G. Kehner, A. Cowan, L. Liu-Chen
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 May 2001
The binding of norBUP to opioid and nociceptin/orphanin FQ (ORL1) receptors, and its effects on [(35)S]guanosine-5'-O-(gamma-thio)triphosphate ([(35]S]GTP gamma S) binding mediated by opioid or ORL1 receptors are described and highlighted.
Statistical analysis of drug-drug and site-site interactions with isobolograms.
- R. Tallarida, F. Porreca, A. Cowan
- BiologyLife Science
- 1989
Buprenorphine: a unique drug with complex pharmacology.
Evidence is provided demonstrating that the ORL-1 receptor plays a functional role not only in the antinociceptive effect of buprenorphine but also in other actions of the drug as well.
AGONIST AND ANTAGONIST PROPERTIES OF BUPRENORPHINE, A NEW ANTINOCICEPTIVE AGENT
- A. Cowan, J. Lewis, I. R. Macfarlane
- Biology, ChemistryBritish Journal of Pharmacology
- 1 August 1977
In rodent antinociceptive assays (writhing, tail pressure), buprenorphine had an action which was rapid in onset and of long duration; it was 25‐40 timesMore potent than morphine after parenteral injection and 7‐10 times more potent after oral administration.
A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1.
- Ning Zhang, S. Inan, J. Oppenheim
- BiologyProceedings of the National Academy of Sciences…
- 22 March 2005
That a proinflammatory chemokine, by interacting with its receptor on small-diameter neurons, sensitizes TRPV1 reveals a previously undescribed mechanism of receptor cross-sensitization that may contribute to hyperalgesia during inflammation.
Targeting of the Orphan Receptor GPR35 by Pamoic Acid: A Potent Activator of Extracellular Signal-Regulated Kinase and β-Arrestin2 with Antinociceptive Activity
- Pingwei Zhao, Haleli Sharir, M. Abood
- Biology, ChemistryMolecular Pharmacology
- 1 October 2010
It is found that pamoic acid induces a Gi/o-linked, GPR35-mediated increase in the phosphorylation of extracellular signal-regulated kinase 1/2, recruitment of β-arrestin2 to G PR35, and internalization of GPR 35, indicating an antinociceptive effect in mice.
pA2 and receptor differentiation: a statistical analysis of competitive antagonism.
- R. Tallarida, A. Cowan, M. Adler
- BiologyLife Science
- 20 August 1979
The rat paw formalin test: comparison of noxious agents
- H. Wheeler-Aceto, F. Porreca, A. Cowan
- BiologyPain
- 1 February 1990
THE ANIMAL PHARMACOLOGY OF BUPRENORPHINE, AN ORIPAVINE ANALGESIC AGENT
1 The general pharmacology of buprenorphine, a potent analgesic agent derived from oripavine, is described.
2-Methoxymethyl-Salvinorin B Is a Potent κ Opioid Receptor Agonist with Longer Lasting Action in Vivo Than Salvinorin A
- Yulin Wang, Yong Chen, L. Liu-Chen
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 March 2008
MOM-Sal B is a potent and efficacious KOPR agonist with longer lasting in vivo effects than Sal A, and was more potent than U50,488H in both tests and more efficacious in the hot-plate test.
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