Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome
Evidence is provided that grafting of adult neural stem cells into a rat thoracic spinal cord weight-drop injury improves motor recovery but also causes aberrant axonal sprouting associated with allodynia-like hypersensitivity of forepaws.
Messenger plasticity in primary sensory neurons following axotomy and its functional implications
Differential influence of nerve growth factor on neuropeptide expression in vivo: a novel role in peptide suppression in adult sensory neurons
The results show that NGF can regulate peptide expression differentially and may also be part of the signal that allows reversion to normal of responses to injury as axons regenerate.
Increase of galanin-like immunoreactivity in rat dorsal root ganglion cells after peripheral axotomy
Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor
- Bjorn Johansson, L. Halldner, B. Fredholm
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 24 July 2001
A1Rs do not play an essential role during development, and although they significantly influence synaptic activity, they play a nonessential role in normal physiology under pathophysiological conditions, including noxious stimulation and oxygen deficiency, they are important.
Nitric oxide synthase‐like immunoreactivity in lumbar dorsal root ganglia and spinal cord of rat and monkey and effect of peripheral axotomy
It is demonstrated that axotomy in rat induces a marked upregulation of NOS synthesis in primary sensory neurons, thus suggesting a role for NO in lesioned sensory neurons.
Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo
It is shown that a 21-mer PNA, complementary to the human galanin receptor type 1 mRNA, coupled to the cellular transporter peptides, transportan or pAntennapedia, is efficiently taken up into Bowes cells where they block the expression of Galanin receptors.
Reduced antinociception and plasma extravasation in mice lacking a neuropeptide Y receptor
It is concluded that the Y1 receptor is required for central physiological and pharmacological NPY-induced analgesia and that its activation is both sufficient and required for the release of substance P and initiation of neurogenic inflammation.
Sex differences in pain perception.
- Z. Wiesenfeld‐Hallin
- Psychology, BiologyGender Medicine
- 1 September 2005
Expression of neuropeptide Y and neuropeptide Y (Y1) receptor mRNA in rat spinal cord and dorsal root ganglia following peripheral tissue inflammation
The distinct upregulation of NPY and NPY (Y1) receptor in response to peripheral inflammation suggests an involvement ofNPY in the response to inflammation and in nociception.