C. Advenier

Publications345
h-index43
Citations6,839
Highly Influential Citations161
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A potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor.
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Effect of indacaterol, a novel long-acting β2-agonist, on isolated human bronchi
TLDR
In isolated human bronchi, indacaterol behaved as a long-acting β2-adrenoceptor agonist with high intrinsic efficacy and fast onset of action that did not antagonise the isoprenaline response.
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Relaxant effects and durations of action of formoterol and salmeterol on the isolated human bronchus.
The objective of this study was to evaluate the potency and efficacy (intrinsic activity) of formoterol and salmeterol and their duration of action in comparison with other beta-adrenoceptor agonists…
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Nerve growth factor and its receptors in asthma and inflammation.
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Contractile activity of three endothelins (ET‐1, ET‐2 and ET‐3) on the human isolated bronchus
TLDR
Et‐1 appears to be the most potent of these three substances in its effect on the human isolated bronchus; its activity seems to involve the action of voltage‐dependent calcium channels at low concentrations, whereas other mechanisms are involved at higher concentrations.
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Neurokinin A (NK2) receptor revisited with SR 48968, a potent non-peptide antagonist.
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Role of potassium channels and nitric oxide in the effects of iloprost and prostaglandin E1 on hypoxic vasoconstriction in the isolated perfused lung of the rat
TLDR
In the rat isolated lung preparation, iloprost and forskolin but not PGE1 dilate pulmonary vessels partly through KATP channels, KCa channels and nitric oxide release, and the results suggest that the role of cyclic AMP in these effects is not unequivocal.
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CONTRIBUTION OF PROSTAGLANDINS AND THROMBOXANES TO THE ADENOSINE AND ATP‐INDUCED CONTRACTION OF GUINEA‐PIG ISOLATED TRACHEA
TLDR
In in vitro experiments adenosine 5′‐triphosphate (ATP) andadenosine were found to exert different effects on the guinea‐pig isolated trachea depending on whether the trachee had previously been contracted with acetylcholine (ACh) or was at resting tone, which suggests an indirect mechanism of action with release of arachidonic acid derivatives.
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mRNA expression of tachykinins and tachykinin receptors in different human tissues.
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Bioavailability, antinociceptive and antiinflammatory properties of BP 2-94, a histamine H3 receptor agonist prodrug.
TLDR
From its pharmacokinetics and pharmacological profile BP 2-94 appears to be a promising novel therapeutic agent in disorders such as asthma, migraine or a variety of inflammatory diseases and pain associated with these disorders.
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