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Brain-Derived Neurotrophic Factor Induces Long-Term Potentiation in Intact Adult Hippocampus: Requirement for ERK Activation Coupled to CREB and Upregulation of Arc Synthesis
TLDR
The results support a model in which BDNF triggers long-lasting synaptic strengthening through MEK-ERK and selective induction of the dendritic mRNA speciesArc, and in situ hybridization showed that Arc transcripts are rapidly and extensively delivered to granule cell dendrites.
Induction of c-fos-like protein in spinal cord neurons following sensory stimulation
TLDR
Physiological stimulation of rat primary sensory neurons causes the expression of c-fos-protein-like immunoreactivity in nuclei of postsynaptic neurons of the dorsal horn of the spinal cord, suggesting that synaptic transmission may induce rapid changes in gene expression in certain post Synaptic neurons.
Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways
TLDR
It is concluded that NK1-positive spinal projection neurons, activated by primary afferent input, project to higher brain areas that control spinal excitability—and therefore pain sensitivity—primarily through descending pathways from the brainstem.
The molecular dynamics of pain control
TLDR
The cellular and neurobiological consequences of pain, especially those that are involved in the generation and maintenance of chronic pain, are emphasized, to significantly alter the approach to pain control and the development of new analgesics.
Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis.
TLDR
It is proposed that it is an amphiphysin heterodimer that drives the recruitment of dynamin to clathrin-coated pits in endocytosing nerve terminals and activates dynamin's GTPase activity in vitro.
Observations on the projections and intrinsic organization of the pigeon optic tectum: An autoradiographic study based on anterograde and retrograde, axonal and dendritic flow
Three aspects of the labelling pattern seen after the injection of 13 different radioactive amino acids into the pigeon optic tectum have been described: The efferent projections of the optic tectum;
Local Translation in Primary Afferent Fibers Regulates Nociception
TLDR
It is found that rapamycin blunted the heightened response to mechanical stimulation that develops around a site of injury and reduced the long-term mechanical hypersensitivity that follows partial peripheral nerve damage - a widely used model of chronic pain.
A Rapamycin-Sensitive Signaling Pathway Is Essential for the Full Expression of Persistent Pain States
TLDR
It is shown that persistent pain states, but not acute pain behavior, are substantially alleviated by centrally administered rapamycin, an inhibitor of the mTOR pathway, and this work suggests a new pharmacological route for therapeutic intervention in persistentPain states.
Rewarding effects of opiates are absent in mice lacking the receptor for substance P
TLDR
It is concluded that substance P has an important and specific role in mediating the motivational aspects of opiates and may represent a new pharmacological route for the control of drug abuse.
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