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Electrophysiological classification of guillain‐barré syndrome: Clinical associations and outcome
We performed electrophysiological and serological testing within 15 days of symptom onset on 369 patients with Guillain‐Barré Syndrome (GBS) enrolled in a trial comparing plasma exchange, intravenousExpand
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Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos.
Proximal spinal muscular atrophy is an autosomal recessive human disease of spinal motor neurons leading to muscular weakness with onset predominantly in infancy and childhood. With an estimatedExpand
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Fatigue in multiple sclerosis: a comparison of different rating scales and correlation to clinical parameters
Objectives: Fatigue is one of the most common, yet poorly defined, disabling symptoms in patients with multiple sclerosis (MS). To delineate more clearly the frequency and type of fatigue, we firstExpand
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Hypermyelination and demyelinating peripheral neuropathy in Pmp22-deficient mice
Peripheral myelin protein PMP22 has been suggested to have a role in peripheral nerve myelination and cell proliferation. Defects at the PMP22 locus are associated with peripheral neuropathies suchExpand
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Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice.
The gap junctional protein connexin32 is expressed in hepatocytes, exocrine pancreatic cells, Schwann cells, and other cell types. We have inactivated the connexin32 gene by homologous recombinationExpand
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Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis.
Experimental autoimmune encephalomyelitis (EAE) is widely regarded as an animal model of the human disease multiple sclerosis. A multitude of studies has investigated the neuroantigen-specific T-cellExpand
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Specific Subtypes of Cutaneous Mechanoreceptors Require Neurotrophin-3 Following Peripheral Target Innervation
Neurotrophin-3 (NT-3) is required for the development of most sensory neurons of the dorsal root ganglia. Using electrophysiological techniques in mice with null mutations of the NT-3 gene, we showExpand
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Neutralizing antibodies to interleukin 1-receptor reduce pain associated behavior in mice with experimental neuropathy
We investigated whether interleukin-1 (IL-1), a mediator of inflammatory pain, also plays a role in pain induced by nerve injury. Female C57BL/6-mice with a chronic constrictive injury of one sciaticExpand
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Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques.
BACKGROUND A number of enzymatic techniques have recently been developed to detect DNA fragmentation in apoptosis at the cellular level. However, since DNA fragmentation also occurs in cellularExpand
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CNTF is a major protective factor in demyelinating CNS disease: A neurotrophic cytokine as modulator in neuroinflammation
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). So far, immunological mechanisms responsible for demyelination have been the focus of interest. However,Expand
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