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recombinant soluble CD4

Known as: sT4 (recombinant), sT4, soluble T4 
A recombinant form of CD4 antigen with anti-HIV application. Recombinant soluble T4 antigen (rsT4) is derived from cell surface antigen CD4 lacking… 
National Institutes of Health

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4 relations

Broader (3)

Anti-HIV AgentsCD4 AntigensRecombinant Proteins

Narrower (1)

recombinant soluble human CD4 protein

Papers overview

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1999
1999
Characterization of the noncovalent complex of human immunodeficiency virus glycoprotein 120 with its cellular receptor CD4 by matrix-assisted laser desorption/ionization mass spectrometry.
The initial event in infection by the human immunodeficiency virus type 1 (HIV-1) is the interaction of the viral envelope… 
Highly Cited
1996
Highly Cited
1996
Binding of HIV-1 virions or gp120-anti-gp120 immune complexes to HIV-1-infected quiescent peripheral blood mononuclear cells reveals latent infection.
HIV-1-infected quiescent CD4+ cells harbor the virus in an inactive state until subsequent activation. The possibility that HIV-1… 
1994
1994
The effects of high-dose recombinant soluble CD4 on human immunodeficiency virus type 1 viremia.
In vitro, low-passage clinical human immunodeficiency virus type 1 (HIV-1) isolates require up to 1000 times greater serum levels… 
Highly Cited
1993
Highly Cited
1993
Resistance of a human serum-selected human immunodeficiency virus type 1 escape mutant to neutralization by CD4 binding site monoclonal antibodies is conferred by a single amino acid change in gp120
We have selected an HXB2 variant which can replicate in the presence of a neutralizing human serum. Sequencing of the gp120… 
1992
1992
Conjugation of soluble CD4 without loss of biological activity via a novel carbohydrate-directed cross-linking reagent.
Highly Cited
1991
Highly Cited
1991
Blocking of human immunodeficiency virus infection depends on cell density and viral stock age
Quantitative infectivity assays were used to study how the blocking activity of soluble CD4 (sCD4) is affected by sCD4… 
Highly Cited
1990
Highly Cited
1990
Characterization of recombinant gp120 and gp160 from HIV-1: binding to monoclonal antibodies and soluble CD4.
We compared four preparations of recombinant HIV-1 envelope glycoprotein: mammalian (Chinese hamster ovary cells) gp120 (Celltech… 
1990
1990
CD4 immunoadhesin, but not recombinant soluble CD4, blocks syncytium formation by human immunodeficiency virus type 2-infected lymphoid cells
Recombinant soluble CD4 (rCD4) has been shown to be an effective inhibitor of human immunodeficiency virus type 1 (HIV-1) and HIV… 
Highly Cited
1989
Highly Cited
1989
Effect of recombinant soluble CD4 in rhesus monkeys infected with simian immunodeficiency virus of macaques
The CD4 molecule is a high-affinity cell-surface receptor for the human immunodeficiency virus (HIV-1)1 and a soluble truncated… 
Highly Cited
1989
Highly Cited
1989
Synergistic inhibition of human immunodeficiency virus type 1 (HIV-1) replication in vitro by recombinant soluble CD4 and 3'-azido-3'-deoxythymidine.
A combination of antiviral therapies that target different sites in the human immunodeficiency virus type 1 (HIV-1) replicative… 
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