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The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
It is concluded that the CD4 antigen is an essential and specific component of the receptor for the causative agent of AIDS.
Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV
Four virus proteins similar to two human macrophage inflammatory protein (MIP) chemokines, interleukin-6 (IL-6), and interferon regulatory factor (IRF) are encoded by the Kaposi's sarcoma-associated…
The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
High-titer packaging cells producing recombinant retroviruses resistant to human serum
Direct comparison with previous retroviral packaging systems indicated that 100-fold-higher titers of helper-free recombinant viruses were released by the FLYA13 and FLYRD18 lines.
HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphoma.
Plasmablastic lymphoma associated with MCD is a new disease entity associated with HHV-8 infection, and it is shown that the frank plasmablast lymphoma that develops in patients with this plasmsablastic variant of M CD is also positive for HHv-8 and lambda light chain.
Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma.
- N. Dupin, C. Fisher, C. Boshoff
- Biology, MedicineProceedings of the National Academy of Sciences…
- 13 April 1999
No staining for LNA-1 is seen in samples from multiple myeloma, prostate cancer, and angiosarcoma, supporting the absence of any etiological link between these diseases and HHV-8.
Clonal Origin and Evolution of a Transmissible Cancer
Prevalence of Kaposi's sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen
How does HIV cause AIDS
- R. Weiss
- Medicine, Biology
- 28 May 1993
Overall, it is increasingly evident that both the tropism and burden of HIV infection correlate closely with the manifestations of disease.
The pH independence of mammalian retrovirus infection.
- M. Mcclure, M. Sommerfelt, M. Marsh, R. Weiss
- Biology, MedicineJournal of General Virology
- 1 April 1990
VSV (MLV-E) pseudotype infection in five out of six mouse and rat cell lines was inhibited by NH4Cl, indicating that infection proceeds via receptor-mediated endocytosis, and it is postulated that the pH-independent entry and cell fusion of XC cells by MLV- E may result from the activity of a cell surface proteinase that cleaves viral gp70 at neutral pH.