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The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
It is concluded that the CD4 antigen is an essential and specific component of the receptor for the causative agent of AIDS. Expand
Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV
Four virus proteins similar to two human macrophage inflammatory protein (MIP) chemokines, interleukin-6 (IL-6), and interferon regulatory factor (IRF) are encoded by the Kaposi's sarcoma-associatedExpand
The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
The studies support a mechanism of AIDS virus infection that initially involves the specific interaction of theAIDS virus with T4 molecules on the cell surface, and find that the T4 gene is expressed in the brain as well as in lymphoid cells, providing an explanation for the dual neurotropic and lymphotropic character of the AIDS virus. Expand
High-titer packaging cells producing recombinant retroviruses resistant to human serum
Direct comparison with previous retroviral packaging systems indicated that 100-fold-higher titers of helper-free recombinant viruses were released by the FLYA13 and FLYRD18 lines. Expand
Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma.
No staining for LNA-1 is seen in samples from multiple myeloma, prostate cancer, and angiosarcoma, supporting the absence of any etiological link between these diseases and HHV-8. Expand
HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphoma.
Plasmablastic lymphoma associated with MCD is a new disease entity associated with HHV-8 infection, and it is shown that the frank plasmablast lymphoma that develops in patients with this plasmsablastic variant of M CD is also positive for HHv-8 and lambda light chain. Expand
Clonal Origin and Evolution of a Transmissible Cancer
Phylogenetic analyses indicate that CTVT most likely originated from a wolf or an East Asian breed of dog between 200 and 2500 years ago and has a remarkably stable genotype. Expand
How does HIV cause AIDS
Overall, it is increasingly evident that both the tropism and burden of HIV infection correlate closely with the manifestations of disease. Expand
Prevalence of Kaposi's sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen
The distribution of antibodies to both a capsid-related recombinant protein and latent antigen of KSHV strongly supports the view that infection with this virus is largely confined to individuals with, or at increased risk for, KS. Expand
Host range and interference studies of three classes of pig endogenous retrovirus.
All PERVs could infect pig cells, indicating that the PERVs have a potential to replicate in pig transplants in immunosuppressed patients and casting doubt on the utility of nonhuman primates as models for PERV zoonosis. Expand