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SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
TLDR
It is demonstrated that SAMHD1 is an antiretroviral protein expressed in cells of the myeloid lineage that inhibits an early step of the viral life cycle, and is probably required for HIV-1 restriction. Expand
SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates
TLDR
It is found that SAMHD1 restricted infection by hydrolyzing intracellular deoxynucleoside triphosphates (dNTPs), lowering their concentrations to below those required for the synthesis of the viral DNA by reverse transcriptase (RT). Expand
Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencing.
TLDR
The evidence that HIV-1 encodes viral siRNA precursors in its genome is reported and that natural HIV- 1 infection provokes nucleic acid-based immunity in human cells is reported. Expand
Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1.
TLDR
The results uncover the phosphorylation of SAMHD1 at Thr592 by cyclin A2/CDK1 as a key regulatory mechanism of its antiviral activity. Expand
HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP.
TLDR
The purified HIV-1 Tat-associated factors from HeLa nuclear extract are purified and show that Tat forms two distinct and stable complexes, Tatcom1 and Tatcom2, which are important for P-TEFb function. Expand
Suppression of MicroRNA-Silencing Pathway by HIV-1 During Virus Replication
TLDR
It is shown that type III RNAses Dicer and Drosha, responsible for miRNA processing, inhibited virus replication both in peripheral blood mononuclear cells from HIV-1–infected donors and in latently infected cells. Expand
HIV‐1 Tat transcriptional activity is regulated by acetylation
TLDR
It is shown that p300 and PCAF also directly acetylate Tat, suggesting that acetylation of Tat regulates two discrete and functionally critical steps in transcription, binding to an RNAP II CTD‐kinase and release of Tat from TAR RNA. Expand
Selective CXCR4 antagonism by Tat: implications for in vivo expansion of coreceptor use by HIV-1.
TLDR
The HIV-1 Tat protein, which is secreted from virus-infected cells, is a CXCR4-specific antagonist that selectively inhibited the entry and replication of X4, but not R5, virus in peripheral blood mononuclear cells (PBMCs). Expand
Mechanism of Transdominant Inhibition of CCR5-mediated HIV-1 Infection by ccr5Δ32*
TLDR
CCR5/ccr5Δ32 heterodimerization as a molecular explanation for the delayed onset of AIDS in heterozygous individuals is suggested. Expand
Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65.
TLDR
It is proposed that acetylation of p65 plays a key role in IkappaBetaalpha-mediated attenuation of NF-kappaBeta transcriptional activity which is an important process that restores the latent state in post-induced cells. Expand
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