J. McKeating

Publications257
h-index72
Citations22,674
Highly Influential Citations1,181
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Complete Replication of Hepatitis C Virus in Cell Culture
Many aspects of the hepatitis C virus (HCV) life cycle have not been reproduced in cell culture, which has slowed research progress on this important human pathogen. Here, we describe a full-length… Expand
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Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry
Hepatitis C virus (HCV) is a leading cause of cirrhosis and liver cancer worldwide. A better understanding of the viral life cycle, including the mechanisms of entry into host cells, is needed to… Expand
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Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles
HIV pseudotypes bearing native hepatitis C virus (HCV) glycoproteins (strain H and Con1) are infectious for the human hepatoma cell lines Huh-7 and PLC/PR5. Infectivity depends on coexpression of… Expand
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Highly Permissive Cell Lines for Subgenomic and Genomic Hepatitis C Virus RNA Replication
ABSTRACT Hepatitis C virus (HCV) replication appears to be restricted to the human hepatoma cell line Huh-7, indicating that a favorable cellular environment exists within these cells. Although… Expand
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Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage.
To define predictors of survival time in late human immunodeficiency virus type 1 (HIV-1) disease, long- and short-duration survivors were studied after their CD4+ T cells fell to </=50/mm3. Immune… Expand
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Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge
A major problem in hepatitis C virus (HCV) immunotherapy or vaccine design is the extreme variability of the virus. We identified human monoclonal antibodies (mAbs) that neutralize genetically… Expand
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Characterization of Hepatitis C Virus E2 Glycoprotein Interaction with a Putative Cellular Receptor, CD81
ABSTRACT A truncated soluble form of the hepatitis C virus E2 glycoprotein, E2661, binds specifically to the surface of cells expressing human CD81 (hCD81) but not other members of the tetraspanin… Expand
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EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy
Hepatitis C virus (HCV) is a major cause of liver disease, but therapeutic options are limited and there are no prevention strategies. Viral entry is the first step of infection and requires the… Expand
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CD81 Is Required for Hepatitis C Virus Glycoprotein-Mediated Viral Infection
ABSTRACT CD81 has been described as a putative receptor for hepatitis C virus (HCV); however, its role in HCV cell entry has not been characterized due to the lack of an efficient cell culture… Expand
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Persistent Hepatitis C Virus Infection In Vitro: Coevolution of Virus andHost
ABSTRACT The virological and cellular consequences of persistent hepatitis C virus (HCV) infection have been elusive due to the absence of the requisite experimental systems. Here, we report the… Expand
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