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- Publications
- Influence
Complete Replication of Hepatitis C Virus in Cell Culture
- B. Lindenbach, M. Evans, +8 authors C. Rice
- Biology, Medicine
- Science
- 22 July 2005
Many aspects of the hepatitis C virus (HCV) life cycle have not been reproduced in cell culture, which has slowed research progress on this important human pathogen. Here, we describe a full-length… Expand
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry
Hepatitis C virus (HCV) is a leading cause of cirrhosis and liver cancer worldwide. A better understanding of the viral life cycle, including the mechanisms of entry into host cells, is needed to… Expand
Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles
- M. Hsu, J. Zhang, +4 authors J. McKeating
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 21 May 2003
HIV pseudotypes bearing native hepatitis C virus (HCV) glycoproteins (strain H and Con1) are infectious for the human hepatoma cell lines Huh-7 and PLC/PR5. Infectivity depends on coexpression of… Expand
Highly Permissive Cell Lines for Subgenomic and Genomic Hepatitis C Virus RNA Replication
- K. J. Blight, J. McKeating, C. Rice
- Biology, Medicine
- Journal of Virology
- 15 December 2002
ABSTRACT Hepatitis C virus (HCV) replication appears to be restricted to the human hepatoma cell line Huh-7, indicating that a favorable cellular environment exists within these cells. Although… Expand
Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage.
- J. Giorgi, L. Hultin, +9 authors R. Detels
- Biology, Medicine
- The Journal of infectious diseases
- 1 April 1999
To define predictors of survival time in late human immunodeficiency virus type 1 (HIV-1) disease, long- and short-duration survivors were studied after their CD4+ T cells fell to </=50/mm3. Immune… Expand
Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge
- M. Law, T. Maruyama, +11 authors D. Burton
- Biology, Medicine
- Nature Medicine
- 2008
A major problem in hepatitis C virus (HCV) immunotherapy or vaccine design is the extreme variability of the virus. We identified human monoclonal antibodies (mAbs) that neutralize genetically… Expand
Characterization of Hepatitis C Virus E2 Glycoprotein Interaction with a Putative Cellular Receptor, CD81
- M. Flint, C. Maidens, +6 authors J. McKeating
- Biology, Medicine
- Journal of Virology
- 1 August 1999
ABSTRACT A truncated soluble form of the hepatitis C virus E2 glycoprotein, E2661, binds specifically to the surface of cells expressing human CD81 (hCD81) but not other members of the tetraspanin… Expand
EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy
- J. Lupberger, M. Zeisel, +23 authors T. Baumert
- Biology, Medicine
- Nature Medicine
- 1 May 2011
Hepatitis C virus (HCV) is a major cause of liver disease, but therapeutic options are limited and there are no prevention strategies. Viral entry is the first step of infection and requires the… Expand
CD81 Is Required for Hepatitis C Virus Glycoprotein-Mediated Viral Infection
- J. Zhang, G. Randall, A. Higginbottom, P. Monk, C. Rice, J. McKeating
- Biology, Medicine
- Journal of Virology
- 1 February 2004
ABSTRACT CD81 has been described as a putative receptor for hepatitis C virus (HCV); however, its role in HCV cell entry has not been characterized due to the lack of an efficient cell culture… Expand
Persistent Hepatitis C Virus Infection In Vitro: Coevolution of Virus andHost
- J. Zhong, P. Gastaminza, +5 authors F. Chisari
- Biology, Medicine
- Journal of Virology
- 6 September 2006
ABSTRACT The virological and cellular consequences of persistent hepatitis C virus (HCV) infection have been elusive due to the absence of the requisite experimental systems. Here, we report the… Expand