J. McKeating

Publications336
h-index82
Citations26,758
Highly Influential Citations1,215
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Complete Replication of Hepatitis C Virus in Cell Culture
TLDR
A full-length HCV genome that replicates and produces virus particles that are infectious in cell culture (HCVcc) is described, suggesting that this in vitro system will aid in the search for improved antiviral compounds.
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry
TLDR
Using an iterative expression cloning approach, claudin-1 (CLDN1), a tight junction component that is highly expressed in the liver, is identified as essential for HCV entry and a new target for antiviral drug development.
Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles
TLDR
HIV–HCV pseudotype infectivity was inhibited by a recombinant soluble form of CD81 and a mAb specific for CD81, suggesting that CD81 may be a component of a receptor complex.
Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage.
TLDR
Through mechanisms apparently unrelated to higher virus burden, immune activation is a major determinant of survival in advanced HIV-1 disease.
Highly Permissive Cell Lines for Subgenomic and Genomic Hepatitis C Virus RNA Replication
TLDR
It is demonstrated that self-replicating subgenomic RNA could be eliminated from Huh-7 clones by prolonged treatment with alpha interferon (IFN-α) and that a higher frequency of cured cells could support both sub genomic and full-length HCV replication.
Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge
TLDR
The results provide evidence that broadly neutralizing antibodies to HCV protect against heterologous viral infection and suggest that a prophylactic vaccine against HCV may be achievable.
CD81 Is Required for Hepatitis C Virus Glycoprotein-Mediated Viral Infection
TLDR
A functional role for CD81 as a coreceptor for HCV glycoprotein-dependent viral cell entry is suggested by using a recently developed retroviral pseudotyping system.
EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy
TLDR
Inhibition of RTK function may constitute a new approach for prevention and treatment of HCV infection and show that tyrosine kinase inhibitors have substantial antiviral activity.
Characterization of Hepatitis C Virus E2 Glycoprotein Interaction with a Putative Cellular Receptor, CD81
TLDR
It is demonstrated that ligation of CD81 by E2661 induced aggregation of lymphoid cells and inhibited B-cell proliferation, demonstrating that E2 interaction with CD81 can modulate cell function.
Persistent Hepatitis C Virus Infection In Vitro: Coevolution of Virus andHost
TLDR
The establishment and the characteristics of persistent in vitro infection of human hepatoma-derived cells by a recently described HCV genotype 2a infectious molecular clone reveal the existence of coevolutionary events during persistent HCV infection that favor survival of both virus and host.
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