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A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1
Using a whole-genome association strategy, polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection are identified.
Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes.
The results confirm the importance of cell-mediated immunity in controlling HIV-1 infection and support the exploration of vaccination approaches for preventing infection that will elicit these immune responses.
The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection
- N. Goonetilleke, Michael K P Liu, A. McMichael
- BiologyThe Journal of experimental medicine
- 8 June 2009
Kinetic analysis and mathematical modeling of virus immune escape showed that the contribution of CD8 T cell–mediated killing of productively infected cells was earlier and much greater than previously recognized and that it contributed to the initial decline of plasma virus in acute infection.
Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity
The replication-defective adenovirus is a promising vaccine vector for development of an HIV-1 vaccine and elicited by a replication-incompetent Ad5 vector, used either alone or as a booster inoculation after priming with a DNA vector.
Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination.
The protective efficacy of vaccine-elicited immune responses against a pathogenic SHIV-89.6P challenge in rhesus monkeys is reported, with no evidence of clinical disease or mortality after challenge.
Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells.
Both viruses were found to replicate predominantly in CD4(+) T cells at the portal of entry and in lymphoid tissues, and infection was propagated not only in activated and proliferating T cells but also, surprisingly, in resting T cells.
Isolation of T-cell tropic HTLV-III-like retrovirus from macaques.
The isolation of a T-cell tropic retrovirus from three immunodeficient macaques and one macaque with lymphoma is described, and it is indicated that it is related to the causative agent of acquired immune deficiency syndrome in humans.
A chimeric simian/human immunodeficiency virus expressing a primary patient human immunodeficiency virus type 1 isolate env causes an AIDS-like disease after in vivo passage in rhesus monkeys
It is shown that after two serial in vivo passages by intravenous blood inoculation of naive rhesus monkeys, this SHIV (SHIV-89.6P) induced CD4 lymphopenia and an AIDS-like disease with wasting and opportunistic infections.
Common Genetic Variation and the Control of HIV-1 in Humans
This study provides overwhelming confirmation of three associations previously reported in a genome-wide study and shows further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC).
Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes
Viral escape from CTL recognition may be a major limitation of the CTL-based AIDS vaccines that are likely to be administered to large human populations over the next several years.