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rebamipide

Known as: 2-(4-chlorobenzoylamino)-3-(2(1H)-quinolinon-4-yl)propionic acid, alpha-[(4-Chlorobenzoyl)amino]-1,2-dihydro-2-oxo-4-quinolinepropanoic Acid 
A quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an… 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (5)

AlanineAnti-Ulcer AgentAntioxidantsEnzyme Inhibitors

Narrower (1)

OPC 12759
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Protection of human corneal epithelial cells from TNF-α-induced disruption of barrier function by rebamipide.
PURPOSE TNF-α disrupts the barrier function of cultured human corneal epithelial (HCE) cells. We investigated the effects of the… 
Highly Cited
2011
Highly Cited
2011
Roles of oxidative stress in stomach disorders
The stomach is a sensitive digestive organ that is susceptible and exposed to exogenous pathogens from the diet. In response to… 
Highly Cited
2010
Highly Cited
2010
Rebamipide: a gastrointestinal protective drug with pleiotropic activities
Rebamipide, a gastroprotective drug, was developed in Japan and was proven to be superior to cetraxate, the former most… 
Highly Cited
2005
Highly Cited
2005
NADPH oxidase mediates interleukin-6 expression in cerulein-stimulated pancreatic acinar cells.
Review
2005
Review
2005
15th Anniversary of Rebamipide: Looking Ahead to the New Mechanisms and New Applications
Rebamipide, a gastroprotective drug, was developed in Japan for the treatment of peptic ulcer disease. It was proven superior to… 
Highly Cited
2004
Highly Cited
2004
Rebamipide Increases the Amount of Mucin-like Substances on the Conjunctiva and Cornea in the N-Acetylcysteine-Treated In Vivo Model
Purpose: Rebamipide increases the amount of mucin-like substances in the stomach. We aimed to determine the effects of rebamipide… 
Highly Cited
2003
Highly Cited
2003
Efficacy of Rebamipide as Adjunctive Therapy in the Treatment of Recurrent Oral Aphthous Ulcers in Patients with Behçet’s Disease
AbstractBackground: Behçet’s disease (BD) is a recurrent inflammatory disease involving chronic recurrent oral aphthous ulcers… 
Review
1998
Review
1998
Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing.
Rebamipide, a gastroprotective drug, is a compound selected from over 500 amino acid analogs of 2(1H)-quinolinone tested for… 
Highly Cited
1994
Highly Cited
1994
Rebamipide, a novel antiulcer agent, attenuates Helicobacter pylori induced gastric mucosal cell injury associated with neutrophil derived oxidants.
The effect of rebamipide, a novel antiulcer compound, on Helicobacter pylori activated neutrophil dependent in vitro gastric… 
Highly Cited
1993
Highly Cited
1993
Stimulation of prostaglandin biosynthesis mediates gastroprotective effect of rebamipide in rats
The concept that gastroprotection by agents such as mild irritants, antacids, or sucralfate is prostaglandin (PG)-mediated has… 
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