T. Yoshikawa

Publications748
h-index70
Citations19,669
Highly Influential Citations654
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Oxidation of proximal protein sulfhydryls by phenanthraquinone, a component of diesel exhaust particles.
Diesel exhaust particles (DEP) contain quinones that are capable of catalyzing the generation of reactive oxygen species in biological systems, resulting in induction of oxidative stress. In the… Expand
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Muscle-enriched microRNA miR-486 decreases in circulation in response to exercise in young men
Background: MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation. miRNAs are taken in by intracellular exosomes, secreted into circulation, and taken up by… Expand
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Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease.
AIM To clarify whether nonalcoholic fatty liver disease (NAFLD) increases the risk of cardiovascular disease. METHODS We carried out a prospective observational study with a total of 1637… Expand
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The Severity of Ultrasonographic Findings in Nonalcoholic Fatty Liver Disease Reflects the Metabolic Syndrome and Visceral Fat Accumulation
BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is closely associated with the metabolic syndrome.AIM:We evaluated the association among the metabolic syndrome, visceral fat accumulation, and the… Expand
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Oxidative stress and delayed-onset muscle damage after exercise.
Reactive oxygen species (ROS) produced during exercise may be involved in delayed-onset muscle damage related to inflammation. To investigate this hypothesis, we studied whether oxidative stress… Expand
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Helicobacter pylori: a ROS-inducing bacterial species in the stomach
BackgroundReactive oxygen species (ROS) and reactive nitrogen species (RNS) have been reported to impact gastric inflammation and carcinogenesis. However, the precise mechanism by which Helicobacter… Expand
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Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population
BackgroundA reliable and inexpensive noninvasive marker of hepatic fibrosis is required in patients with nonalcoholic fatty liver disease (NAFLD). FIB4 index (based on age, aspartate aminotransferase… Expand
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Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease
Aims:  Hepatic steatosis and iron cause oxidative stress, thereby progressing steatosis to steatohepatitis. We quantified the expression of genes involved in the metabolism of fatty acids and iron in… Expand
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[Autoimmune disease].
Peroxisome proliferator-activated receptors (PPARs) are members for the nuclear hormone receptors superfamily of ligand-activated transcriptional factors. PPARs have diverse function for keeping… Expand
  • 155
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SOX2 identified as a target gene for the amplification at 3q26 that is frequently detected in esophageal squamous cell carcinoma.
SOX2 is a transcription factor with a high-mobility group DNA-binding domain that functions as a master regulator during embryogenesis and organogenesis. We investigated DNA copy number aberrations… Expand
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