T. Yoshikawa

Publications1,332
h-index87
Citations31,966
Highly Influential Citations1,008
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Oxidation of proximal protein sulfhydryls by phenanthraquinone, a component of diesel exhaust particles.
TLDR
It is suggested that phenanthraquinone-mediated destruction of protein sulfhydryls appears to involve the oxidation of presumably proximal thiols and the reduction of molecular oxygen.
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Role of active oxygen, lipid peroxidation, and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in rats.
TLDR
It is suggested that active oxygen species and lipid peroxidation play an important part in the pathogenesis of gastric mucosal injury induced by indomethacin, and that the decreased glutathione peroxidase activity aggravated the injury due to accelerated accumulation of hydrogen peroxide and lipidperoxides in the gastricucosal cell.
View on BMJ
Generation of reactive oxygen species during interaction of diesel exhaust particle components with NADPH-cytochrome P450 reductase and involvement of the bioactivation in the DNA damage.
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The Severity of Ultrasonographic Findings in Nonalcoholic Fatty Liver Disease Reflects the Metabolic Syndrome and Visceral Fat Accumulation
TLDR
The scoring system with abdominal ultrasonography could provide accurate information about hepatic steatosis, visceral obesity, and the metabolic syndrome in apparently healthy people who do not consume alcohol.
View on Wolters Kluwer
Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease.
TLDR
NAFLD is a strong predictor of cardiovascular disease and may play a central role in the cardiovascular risk of MS, and simultaneous inclusion of NAFLD and MS in a multivariate model revealed that NA FLD but not MS retained a statistically significant correlation with cardiovascular disease.
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Diesel exhaust particles enhance antigen-induced airway inflammation and local cytokine expression in mice.
TLDR
The effects of DEP inoculated intratracheally on antigen-induced airway inflammation, local expression of cytokine proteins, and antigen-specific immunoglobulin production in mice are investigated for the first experimental evidence that DEP can enhance the manifestations of allergic asthma.
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A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise
TLDR
Findings suggest that exercise stimulates SPARC secretion from muscle tissues and that SPARC inhibits colon tumorigenesis by increasing apoptosis.
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Muscle-enriched microRNA miR-486 decreases in circulation in response to exercise in young men
TLDR
The reduction in circulating miR-486 may be associated with metabolic changes during exercise and adaptation induced by training and shown a significant negative correlation with VO2max for each subject.
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Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans
TLDR
RA contained in PE was absorbed, conjugated and methylated following intake, with a small proportion of RA being degraded into various components, such as conjugate forms of CAA, FA and COA and these metabolites were then rapidly excreted in the urine.
View on Springer
Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance.
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