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Role of active oxygen, lipid peroxidation, and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in rats.
TLDR
It is suggested that active oxygen species and lipid peroxidation play an important part in the pathogenesis of gastric mucosal injury induced by indomethacin, and that the decreased glutathione peroxidase activity aggravated the injury due to accelerated accumulation of hydrogen peroxide and lipidperoxides in the gastricucosal cell. Expand
Muscle-enriched microRNA miR-486 decreases in circulation in response to exercise in young men
TLDR
The reduction in circulating miR-486 may be associated with metabolic changes during exercise and adaptation induced by training and shown a significant negative correlation with VO2max for each subject. Expand
A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise
TLDR
Findings suggest that exercise stimulates SPARC secretion from muscle tissues and that SPARC inhibits colon tumorigenesis by increasing apoptosis. Expand
Oxidative stress and delayed-onset muscle damage after exercise.
TLDR
The results indicate that delayed-onset muscle damage induced by prolonged exercise is partly related to inflammation via phagocyte infiltration caused by ROS and that alpha-tocopherol (an antioxidant) can attenuate such inflammatory changes. Expand
Helicobacter pylori: a ROS-inducing bacterial species in the stomach
TLDR
Understanding the molecular mechanism behind H. pylori-induced ROS, and its involvement in gastric carcinogenesis, is important for developing new strategies for gastric cancer chemoprevention. Expand
Gut microbiota in the pathogenesis of inflammatory bowel disease
TLDR
Clinical and experimental data suggest dysbiosis may play a pivotal role in the pathogenesis of IBD, and the therapeutic options for manipulating the altered gut microbiota, such as probiotics and fecal microbiota transplantation are reviewed. Expand
SOX2 identified as a target gene for the amplification at 3q26 that is frequently detected in esophageal squamous cell carcinoma.
TLDR
Investigation of DNA copy number aberrations in esophageal squamous cell carcinoma cell lines using a high-density oligonucleotide microarray suggests that SOX2 is likely to be a target of the 3q26 amplification and may therefore be involved in the development or progression of ESCC. Expand
Astaxanthin improves muscle lipid metabolism in exercise via inhibitory effect of oxidative CPT I modification.
TLDR
It is suggested that astaxanthin promoted lipid metabolism rather than glucose utilization during exercise via CPT I activation, which led to improvement of endurance and efficient reduction of adipose tissue with training. Expand
The microRNA miR-696 regulates PGC-1{alpha} in mouse skeletal muscle in response to physical activity.
TLDR
Observations demonstrate that miR-696 is a physical activity-dependent miRNA involved in the translational regulation of PGC-1alpha and skeletal muscle metabolism in mice. Expand
Role of oxygen radical and lipid peroxidation in indomethacin-induced gastric mucosal injury.
TLDR
Both allopurinol, an inhibitor of xanthine oxidase, and neutrophil depletion by intraperitoneal injection of antineutrophil antibody significantly attenuates indomethacin-induced gastric injury. Expand
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