• Publications
  • Influence
Preliminary criteria for classification of adult Still's disease.
We have attempted to design classification criteria for adult Still's disease by analyzing the data obtained through a multicenter survey of 90 Japanese patients with this disease and of 267 controlExpand
  • 1,328
  • 89
Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration.
Oxidative stress has long been linked to the pathogenesis of neurodegenerative diseases; however, whether it is a cause or merely a consequence of the degenerative process is still unknown. We showExpand
  • 352
  • 19
  • PDF
Interaction of anti‐inflammatory drugs with serum proteins, especially with some biologically active proteins
The interaction of clinically established anti‐inflammatory drugs with some proteins has shown these drugs to strongly inhibit heat coagulation of whole serum at a concentration attainable in theExpand
  • 328
  • 9
Recent research into Behçet's disease in Japan.
  • Y. Mizushima
  • Medicine
  • International journal of tissue reactions
  • 1988
Recent studies on Behçet's disease supervised by a national research committee are reported under the headings of epidemiology, the role of streptococcus infection, PMN activity, immunologicalExpand
  • 194
  • 8
Comparison of cyclooxygenase-1 and -2 inhibitory activities of various nonsteroidal anti-inflammatory drugs using human platelets and synovial cells.
Recent studies have shown that cyclooxygenase exists in two isozyme forms. Since differences in the pharmacological profiles of nonsteroidal anti-inflammatory drugs (NSAIDs) might be accounted for byExpand
  • 124
  • 8
Efficacy and safety of iguratimod compared with placebo and salazosulfapyridine in active rheumatoid arthritis: a controlled, multicenter, double-blind, parallel-group study
We conducted a 28-week, randomized, double-blind, parallel-group study of iguratimod in 376 Japanese patients with active rheumatoid arthritis to compare the efficacy and safety of the drug withExpand
  • 68
  • 8
Ear Involvement in Patients with Rheumatoid Arthritis
Objective: This study evaluates the degree of hearing impairment in patients with rheumatoid arthritis (RA) and examines the correlation between hearing impairment and the clinical data or chemicalExpand
  • 48
  • 7
Constitutive expression of IL-6 receptors and their role in the excessive B cell function in patients with systemic lupus erythematosus.
Excessive B cell function including autoantibody production is a common feature of SLE and considered to be intimately associated with spontaneous lymphokine secretion by themselves. To clarify rolesExpand
  • 110
  • 5
Excessive function of peripheral blood neutrophils from patients with Behçet's disease and from HLA-B51 transgenic mice.
OBJECTIVE To elucidate the role played by HLA-B51 in the neutrophil hyperfunction of Behçet's disease, we determined the superoxide production by purified peripheral blood neutrophils from Behçet'sExpand
  • 178
  • 5
Tissue distribution and anti-inflammatory activity of corticosteroids incorporated in lipid emulsion.
Dexamethasone palmitate was incorporated into a lipid emulsion (Intralipid, Intralipos) and was injected into rats, and its distribution in the organs and tissues and its anti-inflammatory effectsExpand
  • 132
  • 4