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OPC 12759
Known as:
OPC-12759
National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
rebamipide
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
A multicenter, open-label, 52-week study of 2% rebamipide (OPC-12759) ophthalmic suspension in patients with dry eye.
Shigeru Kinoshita
,
Saki Awamura
,
Norihiro Nakamichi
,
Hiroyuki Suzuki
,
Kazuhide Oshiden
,
N Yokoi
American journal of ophthalmology
2014
PURPOSE To investigate the efficacy and safety of 2% rebamipide ophthalmic suspension administered 4 times daily for 52 weeks in…
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2013
2013
A randomized, multicenter phase 3 study comparing 2% rebamipide (OPC-12759) with 0.1% sodium hyaluronate in the treatment of dry eye.
Shigeru Kinoshita
,
Kazuhide Oshiden
,
Saki Awamura
,
Hiroyuki Suzuki
,
Norihiro Nakamichi
,
N Yokoi
Ophthalmology
2013
OBJECTIVE To investigate the efficacy of 2% rebamipide ophthalmic suspension compared with 0.1% sodium hyaluronate ophthalmic…
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2012
2012
Rebamipide (OPC-12759) in the treatment of dry eye: a randomized, double-masked, multicenter, placebo-controlled phase II study.
Shigeru Kinoshita
,
Saki Awamura
,
Kazuhide Oshiden
,
Norihiro Nakamichi
,
Hiroyuki Suzuki
,
N Yokoi
Ophthalmology
2012
OBJECTIVE To investigate the dose response for efficacy of 1% and 2% rebamipide ophthalmic suspension compared with placebo in…
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2008
2008
Effect of OPC-12759 on EGF receptor activation, p44/p42 MAPK activity, and secretion in conjunctival goblet cells.
José David Ríos
,
Marie A Shatos
,
Hiroki Urashima
,
Darlene Ann Dartt
Experimental eye research
2008
The purpose of the study was to determine if OPC-12759 stimulates secretion from conjunctival goblet cells in culture and if it…
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2006
2006
OPC-12759 increases proliferation of cultured rat conjunctival goblet cells.
José David Ríos
,
Marie A Shatos
,
Hiroki Urashima
,
Hao Quang Tran
,
Darlene Ann Dartt
Cornea
2006
PURPOSE To determine if the gastroprotective drug OPC-12759 increased proliferation of rat conjunctival goblet cells in culture…
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2001
2001
OPC-compounds prevent oxidant-induced carbonylation and depolymerization of the F-actin cytoskeleton and intestinal barrier hyperpermeability.
Ali Banan
,
Leo Fitzpatrick
,
You Cheng Zhang
,
Ali Keshavarzian
Free radical biology & medicine
2001
Rebamipide (OPC-12759), a quinolone derivative, and OPC-6535, a thiazol-carboxylic acid derivative, are compounds with ability to…
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1992
1992
Effect of rebamipide on mucus secretion by endogenous prostaglandin-independent mechanism in rat gastric mucosa.
Kumatoshi Ishihara
,
Yuichi Komuro
,
Naohiro Nishiyama
,
Katsuya Yamasaki
,
Kyoko Hotta
Arzneimittel-Forschung
1992
The effect of rebamipide (2-(4-chlorobenzoylamino)-3-[2 (1H)-quinolinon-4-yl]-propionic acid, OPC-12759, CAS 11911-87-6), an anti…
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1991
1991
[Protective effect of rebamipide (OPC-12759) on the gastric mucosa in rats and humans].
Sunao Kawano
,
N Sato
,
Tomoari Kamada
,
Katsuya Yamasaki
,
Takashi Imaizumi
,
Sadao Komemushi
Nihon yakurigaku zasshi. Folia pharmacologica…
1991
The protective effect of rebamipide against 0.15 N HCl solution containing 40% ethanol (HCl-ethanol)-induced mucosal lesion in…
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1989
1989
Effect of OPC-12759, a novel antiulcer agent, on chronic and acute experimental gastric ulcer, and gastric secretion in rats.
Katsuya Yamasaki
,
Hiroshi Ishiyama
,
Takashi Imaizumi
,
Toshimi Kanbe
,
Youichi Yabuuchi
Japanese journal of pharmacology
1989
The antiulcer effects of OPC-12759, a novel antiulcer agent were compared with those of cetraxate in various experimental ulcer…
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Highly Cited
1987
Highly Cited
1987
Gastric mucosal protection by OPC-12759, a novel antiulcer compound, in the rat.
Katsuya Yamasaki
,
Toshimi Kanbe
,
Takashi Chijiwa
,
Hiroshi Ishiyama
,
Sumiharu Morita
European journal of pharmacology
1987
OPC-12759, 2-(4-chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl]-propionic acid, was studied for its efficacy to prevent the gastric…
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