raltitrexed

Known as: N-[[5-[[(1,4-Dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-L-glutamic Acid, N-(5-(N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino)-2-thenoyl)-L-glutamic acid, TDX 
A quinazoline folate analogue with antineoplastic activity. After transport into cells via the reduced folate carrier, raltitrexed undergoes… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
The TanDEM-X (TerraSAR-X add-on for Digital Elevation Measurement) mission comprises two nearly identical satellites: TerraSAR-X… (More)
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2006
2006
Limited information on salvage treatment in patients affected by pancreatic cancer is available. At failure, about half of the… (More)
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2006
2006
To compare the total plasma cortisol values obtained from three widely used immunoassays and a high pressure liquid… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE We conducted a phase III trial to determine whether first-line treatment with raltitrexed, a thymidine synthase inhibitor… (More)
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Highly Cited
2003
Highly Cited
2003
There is no established second-line treatment for advanced pancreatic cancer after gemcitabine failure. In view of the urgent… (More)
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2002
2002
Thymidylate synthase (TS) is a critical target for chemotherapeutic agents such as 5-fluorouracil (5-FU) and antifolates such as… (More)
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2001
2001
Thymidylate synthase (TS) is a major target in the chemotherapy of colorectal cancer and some other neoplasms while raltitrexed… (More)
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Highly Cited
2000
Highly Cited
2000
Transforming growth factor alpha (TGF-alpha) is an autocrine growth factor for human cancer. Overexpression of TGF-alpha and its… (More)
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Highly Cited
1998
Highly Cited
1998
PURPOSE To compare raltitrexed (Tomudex; Zeneca Pharmaceuticals Ltd, Macclesfield, United Kingdom) a direct, specific thymidylate… (More)
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Review
1998
Review
1998
Since the publication of the results of phase I dose-finding studies, an extensive phase II and III clinical study programme has… (More)
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