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raltitrexed

Known as: N-[[5-[[(1,4-Dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-L-glutamic Acid, N-(5-(N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino)-2-thenoyl)-L-glutamic acid, TDX 
A quinazoline folate analogue with antineoplastic activity. After transport into cells via the reduced folate carrier, raltitrexed undergoes… 
National Institutes of Health

Related topics

Related topics

9 relations

Broader (4)

Antimetabolites, AntineoplasticFolic Acid AntagonistsQuinazolinesThiophenes

Narrower (2)

D1694ZD1694
DNA Synthesis InhibitionNCIt Antineoplastic Agent TerminologyThymidylate Synthase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
In vitro screening of synergistic ascorbate-drug combinations for the treatment of malignant mesothelioma.
2005
2005
Determination of apoptosis, uracil incorporation, DNA strand breaks, and sister chromatid exchanges under conditions of thymidylate deprivation in a model of BER deficiency.
Review
2004
Review
2004
Chemotherapy for malignant pleural mesothelioma: past results and recent developments.
Highly Cited
2003
Highly Cited
2003
Thymidylate synthase expression in advanced colorectal cancer predicts for response to raltitrexed.
PURPOSE The purpose of this research was to evaluate the predictive value of expression of thymidylate synthase (TS) and other… 
Highly Cited
1995
Highly Cited
1995
Pharmacokinetics of HD-MTX in infants, children, and adolescents with non-B acute lymphoblastic leukemia.
A retrospective pharmacokinetic analysis was done of methotrexate serum levels after high-dose treatment (HD-MTX, four cycles at… 
1993
1993
A Comparison of the Accuracy of the TDx-FLM Assay, Lecithin-Sphingomyelin Ratio, and Phosphatidylglycerol in the Prediction of Neonatal Respiratory Distress Syndrome
Objective: To ascertain whether the TDx-FLM assay is a better predictor of neonatal respiratory distress syndrome (RDS) than the… 
1993
1993
Role of the TDx FLM assay in fetal lung maturity.
Highly Cited
1987
Highly Cited
1987
Inhibition of theophylline clearance by coadministered ofloxacin without alteration of theophylline effects
The influence of multiple doses of ofloxacin (ORF 18489) on the disposition of theophylline was studied in 15 male volunteers… 
Highly Cited
1987
Highly Cited
1987
Evaluation of TDx cocaine metabolite assay.
The TDx cocaine metabolite fluorescence polarization immunoassay (Abbott Laboratories) for the detection of benzoylecgonine (BE… 
1987
1987
Detection of morphine in hair with the Abbott TDX.
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