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Thymidylate Synthase

Known as: Synthetase, Thymidylate, dTMP Synthase, Thymidylate Synthase [Chemical/Ingredient] 
Thymidylate synthetase protein (312 aa, ~36 kDa) is encoded by the human TYMS gene. The protein is a conserved transferase enzyme that catalyzes… 
National Institutes of Health

Related topics

Related topics

21 relations
DNA RepairDNA ReplicationEnzyme GeneFolate Biosynthesis Pathway

Broader (1)

Methyltransferase

Narrower (1)

thymidylate synthase-dihydrofolate reductase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Phase I trial of the cyclin-dependent kinase inhibitor and protein kinase C inhibitor 7-hydroxystaurosporine in combination with Fluorouracil in patients with advanced solid tumors.
PURPOSE Preclinical studies indicate that the cyclin-dependent kinase and protein kinase C inhibitor 7-hydroxystaurosporine (UCN… 
Highly Cited
2002
Highly Cited
2002
Thymidylate synthase gene polymorphism predicts response to capecitabine in advanced colorectal cancer
Abstract. Thymidylate synthase is a target enzyme for chemotherapeutic agents such as 5-fluorouracil and capecitabine, its oral… 
Highly Cited
1995
Highly Cited
1995
Effects of lycopene on spontaneous mammary tumour development in SHN virgin mice.
Effects of the chronic ingestion of lycopene, a carotenoid from tomato, on the development of spontaneous mammary tumours were… 
Highly Cited
1989
Highly Cited
1989
Isolation and expression of the Pneumocystis carinii thymidylate synthase gene.
The thymidylate synthase (TS) gene from Pneumocystis carinii has been isolated from complementary and genomic DNA libraries and… 
Highly Cited
1983
Highly Cited
1983
Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
Methotrexate (MTX)-resistant sublines of malignant human cells were selected in vitro by stepwise increase in drug concentration… 
Highly Cited
1983
Highly Cited
1983
Biochemical effects of a quinazoline inhibitor of thymidylate synthetase, N-(4-(N-((2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-l-glutamic acid (CB3717), on human lymphoblastoid…
Highly Cited
1980
Highly Cited
1980
Assessment of growth-limiting events caused by 5-fluorouracil in mouse cells and in human cells.
The purpose of this study was to assess the significance of thymidylate synthetase (dTMP synthetase) inhibition in growth… 
Highly Cited
1980
Highly Cited
1980
Regulation of RNA- and DNA-directed actions of 5-fluoropyrimidines in mouse T-lymphoma (S-49) cells.
The mouse T-lymphoma (S-49) cell line is useful for individually studying RNA- and DNA-directed effects of 5-fluoropyrimidines… 
Highly Cited
1964
Highly Cited
1964
THE SYNTHESIS OF MESSENGER RNA WITHOUT PROTEIN SYNTHESIS. II. SYNTHESIS OF PHAGE-INDUCED RNA AND SEQUENTIAL ENZYME PRODUCTION.
Highly Cited
1960
Highly Cited
1960
Nucleotide interconversions. II. Elevation of deoxycytidylate deaminase and thymidylate synthetase in regenerating rat liver.
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