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Thymidylate Synthase

Known as: Synthetase, Thymidylate, dTMP Synthase, Thymidylate Synthase [Chemical/Ingredient] 
Thymidylate synthetase protein (312 aa, ~36 kDa) is encoded by the human TYMS gene. The protein is a conserved transferase enzyme that catalyzes… 
National Institutes of Health

Related topics

Related topics

21 relations
DNA RepairDNA ReplicationEnzyme GeneFolate Biosynthesis Pathway

Broader (1)

Methyltransferase

Narrower (1)

thymidylate synthase-dihydrofolate reductase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Phase I trial of the cyclin-dependent kinase inhibitor and protein kinase C inhibitor 7-hydroxystaurosporine in combination with Fluorouracil in patients with advanced solid tumors.
PURPOSE Preclinical studies indicate that the cyclin-dependent kinase and protein kinase C inhibitor 7-hydroxystaurosporine (UCN… 
Highly Cited
1989
Highly Cited
1989
Isolation and expression of the Pneumocystis carinii thymidylate synthase gene.
The thymidylate synthase (TS) gene from Pneumocystis carinii has been isolated from complementary and genomic DNA libraries and… 
Highly Cited
1986
Highly Cited
1986
Molecular karyotype of species and subspecies of Leishmania.
Highly Cited
1983
Highly Cited
1983
Biochemical effects of a quinazoline inhibitor of thymidylate synthetase, N-(4-(N-((2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-l-glutamic acid (CB3717), on human lymphoblastoid…
Highly Cited
1983
Highly Cited
1983
Primary structure of the Escherichia coli thyA gene and its thymidylate synthase product.
The nucleotide sequence of a 1,163-base-pair fragment that encodes the entire thyA gene of Escherichia coli K-12 was determined… 
Highly Cited
1976
Highly Cited
1976
Factors affecting substrate binding in Lactobacillus casei thymidylate synthetase as studied by equilibrium dialysis.
The binding of deoxynucleoside 5'-monophosphates and various folate derivatives to Lactobacillus casei thymidylate synthetase was… 
Highly Cited
1975
Highly Cited
1975
Changes of molecular properties associated with the development of resistance against methotrexate in human lymphoblastoid cells.
Highly Cited
1974
Highly Cited
1974
Evidence for a complex regulating the in vivo activities of early enzymes induced by bacteriophage T4.
Abstract An in vivo assay of enzyme activity has been employed to investigate the mechanism of control of enzymes synthesizing… 
Highly Cited
1966
Highly Cited
1966
HeLa cells resistant to bromodeoxyuridine and deficient in thymidine kinase activity
Mutant sublines of HeLa S3 cells resistant to growth inhibition by bromodeoxyuridine (BUdR) have been isolated. The resistant… 
Highly Cited
1960
Highly Cited
1960
Nucleotide interconversions. II. Elevation of deoxycytidylate deaminase and thymidylate synthetase in regenerating rat liver.
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