Thymidylate Synthase

Known as: Synthetase, Thymidylate, dTMP Synthase, Thymidylate Synthase [Chemical/Ingredient] 
Thymidylate synthetase protein (312 aa, ~36 kDa) is encoded by the human TYMS gene. The protein is a conserved transferase enzyme that catalyzes… (More)

Topic mentions per year

Topic mentions per year

1960-2018
010020019602018

Papers overview

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Highly Cited
2003
Highly Cited
2003
Thymidylate synthase (TS) gene expression is modulated by a polymorphism in the 5' regulatory region of the gene. The… (More)
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Highly Cited
2001
Highly Cited
2001
Thymidylate synthase (TS) catalyses the conversion of deoxy-uridylate to deoxy-thymidylate and is essential for DNA synthesis… (More)
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Highly Cited
2001
Highly Cited
2001
PURPOSE To test the hypotheses of whether the relative mRNA expression of the thymidylate synthase (TS) gene and the excision… (More)
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Highly Cited
2000
Highly Cited
2000
We had previously shown that high gene expressions (mRNA levels) of thymidylate synthase (TS; Leichman et al., J. Clin. Oncol… (More)
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Highly Cited
1996
Highly Cited
1996
PURPOSE We tested the hypothesis that polymerase chain reaction (PCR) quantitation of the enzyme thymidylate synthase (TS) within… (More)
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Highly Cited
1995
Highly Cited
1995
Triple tandemly repeated sequences and the corresponding complementary sequence are known to exist in the 5'-terminal regulatory… (More)
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Highly Cited
1995
Highly Cited
1995
Thymidylate synthase (TS) is the target enzyme for 5-fluorouracil (5-FU). We have correlated TS protein and gene expression with… (More)
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Highly Cited
1991
Highly Cited
1991
Thymidylate synthase (TS; 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase, EC 2.1.1.45) is essential for the de novo… (More)
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Highly Cited
1988
Highly Cited
1988
Analysis of a genetic cross of Plasmodium falciparum and of independent parasite isolates from Southeast Asia, Africa, and South… (More)
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Highly Cited
1988
Highly Cited
1988
We describe the isolation and the sequence of the gene for the bifunctional enzyme dihydrofolate reductase-thymidylate synthase… (More)
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