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Nrf2-mediated induction of p62 controls Toll-like receptor-4–driven aggresome-like induced structure formation and autophagic degradation
TLDR
It is demonstrated that p62/SQSTM1 is required for TLR4-mediated autophagy, which it is indicated plays an essential role in the formation and the autophagic degradation of ALIS. Expand
Cancer prevention by natural compounds.
TLDR
Natural agents are advantageous for application to humans because of their combined mild mechanism and here they are reviewed based on in vivo studies with reference to their structures, sources and mechanisms of action. Expand
Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450.
TLDR
Galloylated catechins, ECG and EGCG inhibited the mutagenic activation potently, while EGC and EC showed relatively weak inhibitory effects, suggesting that the inhibition of the enzyme activity of CYP is accounted for partially by the inhibitionof OR. Expand
Antibacterial activity of coriander volatile compounds against Salmonella choleraesuis.
TLDR
The time-kill curve study showed that these alpha,beta-unsaturated aldehydes are bactericidal against S. choleraesuis at any growth stage and that their bactericidal action comes in part from the ability to act as nonionic surfactants. Expand
High catalytic activity of human cytochrome P450 co-expressed with human NADPH-cytochrome P450 reductase in Escherichia coli.
TLDR
When co-expressed with the reductase, human P450 catalyzed the oxidation of representative substrates at efficient rates comparable to the reported activities of P 450 in a reconstituted system containing purified preparations of P450 and the reduCTase. Expand
EFFECTS OF POMEGRANATE JUICE ON HUMAN CYTOCHROME P450 3A (CYP3A) AND CARBAMAZEPINE PHARMACOKINETICS IN RATS
TLDR
It is discovered that a component(s) of pomegranate inhibits the human CYP3A-mediated metabolism of carbamazepine and alters the carbamazetine pharmacokinetics in rats. Expand
Potent inhibition by star fruit of human cytochrome P450 3A (CYP3A) activity.
There has been very limited information on the capacities of tropical fruits to inhibit human cytochrome P450 3A (CYP3A) activity. Thus, the inhibitory effects of tropical fruits on midazolamExpand
Intranuclear verrucomicrobial symbionts and evidence of lateral gene transfer to the host protist in the termite gut
TLDR
It is suggested that this group is widely distributed as intranuclear symbionts of diverse protists in termite guts and that they might have affected the evolution of the host genome through lateral gene transfer. Expand
Metabolic activation of N-alkylnitrosamines in genetically engineered Salmonella typhimurium expressing CYP2E1 or CYP2A6 together with human NADPH-cytochrome P450 reductase.
TLDR
It is concluded that human CYP2E1 is mainly responsible for the metabolic activation of N-nitrosamines with a relatively short alkyl chain(s), whereas CyP2A6 was predominantly responsible forThe metabolic activation for N-alkylnitrosamine possessing a relatively bulky alkyL chain. Expand
Molecular cloning and characterization of rat ST1B1 and human ST1B2 cDNAs, encoding thyroid hormone sulfotransferases.
TLDR
Data indicate that the newly characterized sulfotransferases constitute a distinct ST1 subfamily of enzymes catalyzing the sulfation of T3 as a typical endogenous substrate in rats and humans. Expand
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