DNA Synthesis Inhibition

DNA Synthesis Inhibition involves interference with, or restraint of, the activities involved in the polymeric linkage of deoxyribose moieties (with… (More)
National Institutes of Health

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5,6-dihydro-5-azacytidineBromodeoxyuridineDNADNA Minor Groove Binding Agent SG2000
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2008
2008
Pseudomonas aeruginosa, under DNA replication inhibition, tends to form biofilms via Arr.
Bacteria infecting eukaryotic hosts often encounter therapeutic antimicrobial and DNA damaging agents and respond by forming… (More)
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2007
2007
Different S/M checkpoint responses of tumor and non tumor cell lines to DNA replication inhibition.
Cell cycle checkpoint abrogation, especially the inhibition of Chk1 in combination with DNA-damaging treatments, has been… (More)
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2005
2005
Degradation of human exonuclease 1b upon DNA synthesis inhibition.
In response to DNA damage, signaling pathways are triggered that either block the cell division cycle at defined transitions (G1… (More)
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2002
2002
Bloom's syndrome protein response to ultraviolet-C radiation and hydroxyurea-mediated DNA synthesis inhibition
Bloom's syndrome (BS) arises through mutations in both copies of the BLM gene that encodes a RecQ 3′-5′ DNA helicase. BS patients… (More)
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1998
1998
DNA synthesis inhibition as an indirect mechanism of chromosome aberrations: comparison of DNA-reactive and non-DNA-reactive clastogens.
Positive results in the in vitro assay for chromosome aberrations sometimes occur with test chemicals that apparently do not… (More)
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1993
1993
Primer RNA chain termination induced by 9-beta-D-arabinofuranosyl-2-fluoroadenine 5'-triphosphate. A mechanism of DNA synthesis inhibition.
The studies described herein were aimed at defining the mechanism by which 9-beta-D-arabinofuranosyl-2-fluoroadenine 5… (More)
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1983
1983
Influence of DNA synthesis inhibition on the coordinate expression of core human histone genes during S phase.
Core histone mRNA metabolism has been examined in S phase HeLa cells recovering from DNA synthesis inhibition by 1 mM hydroxyurea… (More)
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1977
1977
The relationship between DNA strand-scission and DNA synthesis inhibition in HeLa cells treated with neocarzinostatin.
Neocarzinostatin inhibits DNA synthesis in HeLa S3 cells and induces the rapid limited breakage of cellular DNA. The… (More)
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1976
1976
Mechanism of DNA synthesis inhibition by arabinosyl cytosine and arabinosyl adenine
1-β-D-ARABINOFURANOSYL CYTOSINE (ara-C) and 9-β-D-arabinofuranosyl adenine (ara-A) are potent antileukaemic and antiviral agents… (More)
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1971
1971
Lymphocyte DNA synthesis inhibition.
A specific endogenous inhibitor for lymphocyte DNA synthesis that can be isolated from the lymphoid system and which is probably… (More)
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