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DNA Synthesis Inhibition

DNA Synthesis Inhibition involves interference with, or restraint of, the activities involved in the polymeric linkage of deoxyribose moieties (with… Expand
National Institutes of Health

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32 relations
5,6-dihydro-5-azacytidineBromodeoxyuridineDNADNA Minor Groove Binding Agent SG2000
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Papers overview

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2008
2008
Pseudomonas aeruginosa, under DNA replication inhibition, tends to form biofilms via Arr.
Bacteria infecting eukaryotic hosts often encounter therapeutic antimicrobial and DNA damaging agents and respond by forming… Expand
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2007
2007
Different S/M checkpoint responses of tumor and non tumor cell lines to DNA replication inhibition.
Cell cycle checkpoint abrogation, especially the inhibition of Chk1 in combination with DNA-damaging treatments, has been… Expand
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Highly Cited
2005
Highly Cited
2005
Degradation of human exonuclease 1b upon DNA synthesis inhibition.
In response to DNA damage, signaling pathways are triggered that either block the cell division cycle at defined transitions (G1… Expand
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2003
2003
The role of DNA synthesis inhibition in the cytotoxicity of 2′,2′-difluoro-2′-deoxycytidine
PurposeCytotoxicity from the anticancer drug 2′,2′-difluoro-2′-deoxycytidine (dFdCyd) has been correlated with its incorporation… Expand
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2002
2002
Bloom's syndrome protein response to ultraviolet-C radiation and hydroxyurea-mediated DNA synthesis inhibition
Bloom's syndrome (BS) arises through mutations in both copies of the BLM gene that encodes a RecQ 3′-5′ DNA helicase. BS patients… Expand
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Highly Cited
1998
Highly Cited
1998
DNA synthesis inhibition as an indirect mechanism of chromosome aberrations: comparison of DNA-reactive and non-DNA-reactive clastogens.
Positive results in the in vitro assay for chromosome aberrations sometimes occur with test chemicals that apparently do not… Expand
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1993
1993
Primer RNA chain termination induced by 9-beta-D-arabinofuranosyl-2-fluoroadenine 5'-triphosphate. A mechanism of DNA synthesis inhibition.
The studies described herein were aimed at defining the mechanism by which 9-beta-D-arabinofuranosyl-2-fluoroadenine 5… Expand
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1989
1989
Comparative cytotoxicity, DNA synthesis inhibition and drug incorporation of eight anthracyclines in a model of doxorubicin-sensitive and -resistant rat glioblastoma cells.
We have compared the growth inhibition, DNA synthesis inhibition and cell incorporation of eight anthracyclines in a model of… Expand
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Highly Cited
1976
Highly Cited
1976
DNA synthesis inhibition and the induction of protein X in Escherichia coli.
The synthesis of protein X (Inouye & Pardee, 1970) is switched on by the inhibition of DNA synthesis. This induction of protein X… Expand
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1971
1971
Lymphocyte DNA Synthesis Inhibition
A specific endogenous inhibitor for lymphocyte DNA synthesis that can be isolated from the lymphoid system and which is probably… Expand
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