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Comparative distribution and embryotoxicity of hydroxyurea in pregnant rats and rhesus monkeys.
Although the teratogenic effects were not identical in the two species, these data are interpreted to mean that rat embryos are teratogenically much more sensitive to hydroxyurea than monkey embryos, which has important implications in the selection of appropriate species for tests to estimate human teratogens risks.
Comparative distribution and embryotoxicity of methotrexate in pregnant rats and rhesus monkeys.
A slow rate of fall in embryo concentrations in both species was estimated to be inversely proportioned to the rate of growth of embryos, which was in accord with the fact that the absolute amount per embryo was little changed in 24 hours.
Potentiation of teratogenesis.
  • E. Ritter
  • Biology
    Fundamental and applied toxicology : official…
  • 1 June 1984
Teratology studies were conducted with rats using combinations of a variety of agents including inhibitors of DNA, RNA, protein, and purine synthesis, and most combinations showed potentiation of embryolethality and teratogenesis as compared to that seen with the use of the individual agents.
Effect of 5-fluoro-2'-deoxyuridine on deoxyribonucleotide pools in vivo.
Elimination of the dGTP pool correlated temporally with the cytotoxicity of FdUrd and extremely rapid fixation of tissue was required to avoid artifactually high deoxyribonucleoside triphosphate values.
Potentiative interactions between caffeine and various teratogenic agents.
It is not clear from the present experiments whether much lower caffeine dosage, as normally encountered in humans, would potentiate embryotoxicity due to other agents.
Teratogenicity of dimethoxyethyl phthalate and its metabolites methoxyethanol and methoxyacetic acid in the rat.
A striking similarity in the defects produced by these agents, mainly hydronephrosis, heart defects, and short limbs and tails, strongly suggests that following the administration of DMEP, 2-ME, or MAA, MAA is the proximate teratogen.
Teratogenesis and inhibition of DNA synthesis induced in rat embryos by cytosine arabinoside.
Embryotoxic effects in 20-day fetuses were more closely related to the cumulative suppression of DNA synthesis caused by a given dosage than with either the level at any one posttreatment interval or the duration of the suppression.