DNA Minor Groove Binding Agent SG2000

Known as: SG2000 
A sequence-selective pyrrolobenzodiazepine (PBD) dimer with potential antineoplastic activity. Following intravenous administration, DNA minor groove… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2010-2017
01220102017

Papers overview

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Review
2017
Review
2017
The pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) are a family of sequence-selective DNA minor-groove binding agents that form a… (More)
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2015
2015
BACKGROUND Cancer is the leading cause of death in older dogs and its prevalence is increasing. There is clearly a need to… (More)
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2013
2013
PURPOSE To evaluate γ-H2AX foci as a pharmacodynamic marker for DNA damage induced by DNA interstrand cross-linking drugs… (More)
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2013
2013
Purpose: To evaluate g-H2AX foci as a pharmacodynamic marker for DNA damage induced by DNA interstrand cross-linking drugs… (More)
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Review
2012
Review
2012
DNA-targeted chemotherapies remain fundamental in clinical management of both common solid tumours and hematologic malignancies… (More)
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2011
2011
The pyrrolobenzodiazepines (PBDs) are naturally occurring antitumor antibiotics and a PBD dimer (SJG-136, SG2000) is in Phase II… (More)
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Review
2011
Review
2011
INTRODUCTION DNA interacting agents play a major role in cancer chemotherapy, either as single agents, in combination drug… (More)
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2010
2010
The pyrrolobenzodiazepines (PBD) are naturally occurring antitumor antibiotics, and a PBD dimer (SJG-136, SG2000) is in phase II… (More)
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2010
2010
The dimeric pyrrolobenzodiazepine SJG-136 (NSC 694501, SG2000) has potent in vitro antiproliferative activity and in vivo… (More)
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