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ZD1694
Known as:
ZD 1694
, ZD-1694
National Institutes of Health
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Review
2005
Review
2005
ZD9331: discovery to clinical development
T. S. Benepal
,
I. Judson
Anti-Cancer Drugs
2005
Corpus ID: 24546306
Thymidylate synthase (TS) has been targeted in cancer therapy for many years. As a result of a prolonged and extensive drug…
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2003
2003
Determination of activity of new antifolate thymidylate synthase inhibitor ZD1694 against cancer cell lines in vitro
Wan Yun
2003
Corpus ID: 76609213
AIM: To investigate the effects of the thymidylate synthase(TS) inhibitor ZD 1694 against cancer cell lines in vitro . METHODS…
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2000
2000
STATE-OF-THE-ART IN THE MANAGEMENT OF CANCER
2000
Corpus ID: 13224268
NON-SMALL-CELL LUNG CANCER-EPIDEMIOLOGY, TUMOR MARKERS, DIAGNOSIS, STAGING, AND PROGNOSIS EPIDEMIOLOGY 1129 Gender Variations in…
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2000
2000
A comparison of the effects of nine folate analogs on early and late murine hematopoietic progenitor cells in vitro
A. Strømhaug
,
D. Warren
Cancer Chemotherapy and Pharmacology
2000
Corpus ID: 20753059
Purpose: Since the clinical introduction of the antifolates aminopterin (AMT) and methotrexate (MTX) many promising analogs have…
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2000
2000
Advances in Brief Antifolate Resistance Mediated by the Multidrug Resistance Proteins MRP 1 and MRP 21
J. H. Hooijberg
,
H. Broxterman
,
+7 authors
G. Jansen
2000
Corpus ID: 17073530
Transfection of multidrug resistance proteins (MRPs) MRP1 and MRP2 in human ovarian carcinoma 2008 cells conferred a marked level…
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1999
1999
Antitumor Activity of ZD 1694 ( Tomudex ) against Human Head and Neck Cancer in Nude Mouse Models : Role of Dosing Schedule and Plasma Thymidine 1
Shou-Song Cao
,
J. McGuire
,
Y. Rustum
1999
Corpus ID: 6740905
We studied the antitumor activity and toxicity of ZD1694 (tomudex), a specific inhibitor of thymidylate synthase (TS), in nude…
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1997
1997
Interference by antifolate drugs in a folate competitive protein-binding assay
A. Hardcastle
,
S. Clarke
,
Wynne Aherne
Cancer Chemotherapy and Pharmacology
1997
Corpus ID: 13089323
Thymidylate synthase (TS, EC 2.1.1.45) and other folatedependent enzymes have recently received much interest as chemotherapeutic…
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1997
1997
p 53 and WAF 1 Are Induced and Rb Protein Is Hypophosphorylated during Cell Growth Inhibition by the Thymidylate Synthase Inhibitor ZD 1694 ( Tomudex )
Ming-Biao Yin
,
W. Voigt
,
+5 authors
Y. Rustum
1997
Corpus ID: 30205065
In a previous study, we found that treatment of HCT-8 cells with ZD1694, a specific antifolate-based thymidylate synthase…
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1995
1995
Fluorouracil: active in ZD1694 (tomudex)-resistant cell lines with markedly elevated thymidylate synthase levels.
P. Johnston
,
K. Behan
,
C. J. Allegra
,
James C. Drake
Journal of the National Cancer Institute
1995
Corpus ID: 28248328
1995
1995
Original Paper 'Tomudex' (ZD1694): Results ofa Randomised Trial in Advanced Colorectal Cancer Demonstrate Efficacy and Reduced Mucositis and Leucopenia
D. Cunningham
,
U. Rath
,
+9 authors
G. Marañón
1995
Corpus ID: 78757345
'Tomudex' (ZDI694), a direct and specific thymidylate synthase (TS) inhibitor entered phase III studies in November 1993. We…
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