Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

ZD1694

Known as: ZD 1694, ZD-1694 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Purpose: Raltitrexed, pemetrexed, lometrexol, and ZD9331 are antifolate drugs transported into cells via the ubiquitously… Expand
  • figure 1
  • table 1
  • table 2
  • table 3
  • figure 2
Is this relevant?
2004
2004
SummaryBackgroundCurrently available therapies for advanced pancreatic cancer offer only palliative benefits, and patients with… Expand
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Thymidylate synthase (TS) is an important target for cancer chemotherapy. However, several mechanisms of resistance to TS… Expand
  • table 1
  • figure 1
  • figure 2
  • table 2
  • table 3
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Transfection of multidrug resistance proteins (MRPs) MRP1 and MRP2 in human ovarian carcinoma 2008 cells conferred a marked level… Expand
  • figure 1
  • table 1
  • figure 2
Is this relevant?
Highly Cited
1998
Highly Cited
1998
CEM/MTX is a subline of human CCRF-CEM leukemia cells which displays >200-fold resistance to methotrexate (MTX) due to defective… Expand
  • figure 1
  • table I
  • figure 2
  • figure 3
  • figure 5
Is this relevant?
Highly Cited
1997
Highly Cited
1997
ZD9331 is a drug that was developed from a potent class of water-soluble, C7-methyl-substituted, quinazoline-based inhibitors of… Expand
  • figure I
  • figure 2
  • figure 3
  • table 2
  • table 4
Is this relevant?
1996
1996
BACKGROUND Thymidylate synthase (TS) catalyzes the reductive methylation of deoxyuridine monophosphate (dUMP) by 5, 10… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1995
Highly Cited
1995
'Tomudex' (ZD1694), a direct and specific thymidylate synthase (TS) inhibitor entered phase III studies in November 1993. We… Expand
Is this relevant?
Review
1995
Review
1995
ZD1694 (Tomudex) is a new antifolate which is a specific inhibitor of thymidylate synthase (TS). Evidence suggests that ZD1694… Expand
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Four cell lines, the mouse L1210 leukaemia, the human W1L2 lymphoblastoid and two human ovarian (CH1 and 41M) cell lines, were… Expand
  • table I
  • table I
  • table IV
  • table V
  • table VIII
Is this relevant?