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The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.
- G. Zaman, M. Flens, H. Broxterman
- BiologyProceedings of the National Academy of Sciences…
- 13 September 1994
It is concluded that MRP is a plasma membrane drug-efflux pump that confers drug resistance in human lung carcinoma cells by generating a subline stably transfected with an expression vector containing MRP cDNA.
Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.
This report provides a mechanistic basis for resistance to polyglutamatable antifolates through an MRP-mediated drug extrusion.
Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations.
Although detection of Pgp and MDR1 is at present likely to be more reliable in leukemias and lymphomas than in solid tumors, accurate measurement of low levels of P gp expression under most conditions remains an elusive goal.
Kinetic analysis of calcein and calcein-acetoxymethylester efflux mediated by the multidrug resistance protein and P-glycoprotein.
Compared to previously published data for anthracyclines, the kinetic data for MRP-mediated CAL-AM pumping are most similar to those for the neutral hydroxydaunorubicin, giving a quantitative account of transport properties of MRP for two related but differently charged compounds.
Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance.
Immunohistochemical staining with a p110-specific monoclonal antibody showed that the molecule has a high expression in normal epithelial cells and tissues chronically exposed to xenobiotics and potentially toxic agents, such as bronchial cells, cells lining the intestines, and kidney tubules.
Platelet: transporter of vascular endothelial growth factor.
- H. Verheul, K. Hoekman, H. Pinedo
- Biology, MedicineClinical cancer research : an official journal of…
- 1 December 1997
Evidence for VEGF transport by platelets is found, indicating that serum V EGF concentrations reflect mainly platelet counts rather than tumor burden in cancer patients, as reported earlier.
Nanomedicine for targeted cancer therapy: towards the overcoming of drug resistance.
Lysosomal Sequestration of Sunitinib: A Novel Mechanism of Drug Resistance
It is reported that sunit inib inhibits tumor cell proliferation at clinically relevant concentrations and found lysosomal sequestration to be a novel mechanism of sunitinib resistance.
Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors.
The wide occurrence of LRP in normal and transformed cells in humans, its similar distribution to that of vaults in other species, as well as the high level of conservation among eukaryotic cells of both the amino acid sequence of the major vault protein and the composition and structure of vault, suggest that vault function is important to eukARYotic cells.