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Quinazolines

Known as: Quinazoline, Quinazolines [Chemical/Ingredient] 
 

Topic mentions per year

Topic mentions per year

1945-2018
05010019452017

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50 relations

Narrower (47)

2,4(1H,3H)-quinazolinedione4-chloro-2-styrylquinazoline5,6,7,8-tetrahydroquinazoline5-(R)-fluorofebrifugine
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antagonists & inhibitorsaspects of radiation effects

Broader (1)

benzodiazine

Related mentions per year

Related mentions per year

1945-2018
19401960198020002020
Quinazolines
gefitinib
bunazosin
CB 3717
vasicine
BIBN 4096BS

Papers overview

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2011
2011
Synthesis and in vitro antitumor activity of substituted quinazoline and quinoxaline derivatives: search for anticancer agent.
The synthesis of some 2-furano-4(3H)-quinazolinones, diamides (open ring quinazolines), quinoxalines and their biological… (More)
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Highly Cited
2009
Highly Cited
2009
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M.
The clinical efficacy of epidermal growth factor receptor (EGFR) kinase inhibitors in EGFR-mutant non-small-cell lung cancer… (More)
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Highly Cited
2005
Highly Cited
2005
AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer.
Inhibition of vascular endothelial growth factor-A (VEGF) signaling is a promising therapeutic approach that aims to stabilize… (More)
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2003
2003
Quinazoline-based α1-adrenoceptor antagonists induce prostate cancer cell apoptosis via TGF-β signalling and IκBα induction
Previous studies documented the ability of quinazoline-based α1-adrenoceptor antagonists to induce apoptosis in prostate cancer… (More)
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2002
2002
Quinazoline-derived alpha1-adrenoceptor antagonists induce prostate cancer cell apoptosis via an alpha1-adrenoceptor-independent action.
Recent evidence suggests that the quinazoline-based alpha1-adrenoceptor antagonists, doxazosin and terazosin, exhibit a potent… (More)
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2001
2001
Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors.
Several inhibitors of EGF receptor (EGFR) tyrosine kinase activity have been developed that compete with ATP at its binding site… (More)
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Highly Cited
2001
Highly Cited
2001
The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells.
The epidermal growth factor receptor (EGFR) is commonly overexpressed in many human tumors and provides a new target for… (More)
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Highly Cited
2000
Highly Cited
2000
Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor.
Transforming growth factor alpha (TGF-alpha) is an autocrine growth factor for human cancer. Overexpression of TGF-alpha and its… (More)
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1997
1997
Unliganded epidermal growth factor receptor dimerization induced by direct interaction of quinazolines with the ATP binding site.
Receptor dimerization is critical for signaling by the epidermal growth factor receptor (EGFR) tyrosine kinase. This occurs after… (More)
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Highly Cited
1991
Highly Cited
1991
ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.
N-(5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N- methylamino]-2-thenoyl)-L-glutamic acid (ICI D1694) is a water… (More)
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