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Prazosin

Known as: 2-[4-(2-furoyl)piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline, Prazosine, 2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline 
A synthetic piperazine derivative and an alpha-1 adrenergic receptor inhibitor used primarily as an anti-hypertensive. Prazosin's effects are most… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
BACKGROUND Prazosin, a central nervous system (CNS) active alpha-1 adrenoreceptor antagonist, has reduced nightmares and sleep… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Excessive brain responsiveness to norepinephrine appears to contribute to post-traumatic stress disorder (PTSD… Expand
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Highly Cited
2003
Highly Cited
2003
OBJECTIVE Prazosin is a centrally active alpha(1) adrenergic antagonist. The authors' goal was to evaluate prazosin efficacy for… Expand
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Highly Cited
1993
Highly Cited
1993
BACKGROUND Characteristics such as age and race are often cited as determinants of the response of blood pressure to specific… Expand
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Highly Cited
1989
Highly Cited
1989
The role of endothelium-derived nitric oxide in the regulation of blood pressure in the anesthetized rabbit was studied with N… Expand
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Highly Cited
1986
Highly Cited
1986
To evaluate the effects of vasodilator therapy on mortality among patients with chronic congestive heart failure, we randomly… Expand
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Highly Cited
1986
Highly Cited
1986
[3H]Prazosin and [3H]WB4101 [2-(2,6-dimethoxyphenoxyethyl)aminomethyl-1,4 benzodioxane] have both been proposed to label alpha 1… Expand
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Highly Cited
1980
Highly Cited
1980
  • S. Langer
  • Pharmacological reviews
  • 1980
  • Corpus ID: 22813919
During norepinephrine release elecited by the arrival of nerve impulses, the neurotransmitter interacts with specific receptors… Expand
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Highly Cited
1980
Highly Cited
1980
In 23 hypertensive men, aged 47-55, propranolol reduced serum high-density-lipoprotein (HDL) cholesterol by 13% reduced the ratio… Expand
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Highly Cited
1977
Highly Cited
1977
To elucidate the hemodynamic effects of prazosin, an antihypertensive agent, in congestive heart failure, we studied 10 patients… Expand
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