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Prazosin

Known as: 2-[4-(2-furoyl)piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline, Prazosine, 2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline 
A synthetic piperazine derivative and an alpha-1 adrenergic receptor inhibitor used primarily as an anti-hypertensive. Prazosin's effects are most… 
National Institutes of Health

Related topics

Related topics

36 relations

Broader (4)

Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAntihypertensive Agentspiperazine
Adrenergic alpha-Antagonists [MoA]Arterial Vasodilation [PE]Decreased Blood Pressure [PE]Drug Allergy

Narrower (13)

HytrinL 765314MinipressMinizide

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1991
Highly Cited
1991
Pituitary adenylate cyclase activating peptide (PACAP) in guinea-pig lung: distribution and dilatory effects
Highly Cited
1990
Highly Cited
1990
Alpha 1-adrenoceptor stimulation increases intracellular pH and Ca2+ in cardiomyocytes through Na+/H+ and Na+/Ca2+ exchange.
Highly Cited
1986
Highly Cited
1986
The vasoconstrictor effect of neuropeptide Y and related peptides in the guinea pig isolated heart
Highly Cited
1984
Highly Cited
1984
Characterization of neurotransmitter receptor-mediated phosphatidylinositol hydrolysis in the rat hippocampus.
Highly Cited
1983
Highly Cited
1983
Negative effects of diuretic drugs on metabolic risk factors for coronary heart disease: possible alternative drug therapies.
Highly Cited
1983
Highly Cited
1983
The effect of alpha- and beta-adrenoceptor antagonist agents on reperfusion ventricular fibrillation and metabolic status in the isolated perfused rat heart.
Highly Cited
1983
Highly Cited
1983
Additive effects of epinephrine and corticotropin-releasing factor (CRF) on adrenocorticotropin release in rat anterior pituitary cells.
Review
1983
Review
1983
Minireview. Catecholamines and the sleep-wake cycle. II. REM sleep.
Highly Cited
1981
Highly Cited
1981
Alpha 2-adrenoreceptors on human platelets: selective labelling by [3H]clonidine and [3H]yohimbine and competitive inhibition by antidepressant drugs.
Highly Cited
1977
Highly Cited
1977
Efficacy of Ambulatory Systemic Vasodilator Therapy with Oral Prazosin in Chronic Refractory Heart Failure: Concomitant Relief of Pulmonary Congestion and Elevation of Pump Output Demonstrated by…
The long-term efficacy of the new oral vasodilator, prazosin (PZ), was evaluated in nine patients with refractory heart failure… 
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