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Prazosin

Known as: 2-[4-(2-furoyl)piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline, Prazosine, 2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline 
A synthetic piperazine derivative and an alpha-1 adrenergic receptor inhibitor used primarily as an anti-hypertensive. Prazosin's effects are most… 
National Institutes of Health

Related topics

Related topics

36 relations

Broader (4)

Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAntihypertensive Agentspiperazine
Adrenergic alpha-Antagonists [MoA]Arterial Vasodilation [PE]Decreased Blood Pressure [PE]Drug Allergy

Narrower (13)

HytrinL 765314MinipressMinizide

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
The effects of stress exposure on prefrontal cortex: Translating basic research into successful treatments for post-traumatic stress disorder
Highly Cited
2013
Highly Cited
2013
α1-Adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice.
Review
2009
Review
2009
A systematic review of the management of autonomic dysreflexia after spinal cord injury.
Highly Cited
2002
Highly Cited
2002
Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells.
Highly Cited
1993
Highly Cited
1993
Single-Drug Therapy for Hypertension in Men -- A Comparison of Six Antihypertensive Agents with Placebo
Background Characteristics such as age and race are often cited as determinants of the response of blood pressure to specific… 
Highly Cited
1990
Highly Cited
1990
Spectral analysis of blood pressure and heart rate in conscious rats: effects of autonomic blockers.
Highly Cited
1986
Highly Cited
1986
Characterization of alpha 1-adrenergic receptor subtypes in rat brain: a reevaluation of [3H]WB4104 and [3H]prazosin binding.
[3H]Prazosin and [3H]WB4101 [2-(2,6-dimethoxyphenoxyethyl)aminomethyl-1,4 benzodioxane] have both been proposed to label alpha 1… 
Review
1985
Review
1985
Heterogeneity of alpha-2 adrenergic receptors
Highly Cited
1981
Highly Cited
1981
Molecular mechanisms involved in α-adrenergic responses
Highly Cited
1977
Highly Cited
1977
Sustained reduction of cardiac impedance and preload in congestive heart failure with the antihypertensive vasodilator prazosin.
To elucidate the hemodynamic effects of prazosin, an antihypertensive agent, in congestive heart failure, we studied 10 patients… 
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