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Prazosin

Known as: 2-[4-(2-furoyl)piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline, Prazosine, 2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline 
A synthetic piperazine derivative and an alpha-1 adrenergic receptor inhibitor used primarily as an anti-hypertensive. Prazosin's effects are most… 
National Institutes of Health

Related topics

Related topics

36 relations

Broader (4)

Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAntihypertensive Agentspiperazine
Adrenergic alpha-Antagonists [MoA]Arterial Vasodilation [PE]Decreased Blood Pressure [PE]Drug Allergy

Narrower (13)

HytrinL 765314MinipressMinizide

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1985
1985
Effect of alpha-adrenoceptor antagonists (phentolamine, nicergoline and prazosin) on reperfusion arrhythmias and noradrenaline release in perfused rat heart.
Rat isolated hearts were perfused through the left atrium with a modified Krebs-Henseleit solution or mounted on a Langendorff… 
1985
1985
Structure-activity relationships for prazosin and WB 4101 analogues as alpha 1-adrenoreceptor antagonists.
Several alpha-adrenoreceptor antagonists were prepared by coupling one of the two moieties of WB 4101 (1) with one of the two… 
1985
1985
Prazosin treatment of Raynaud's phenomenon: a double blind single crossover study.
: The efficacy of prazosin (Minipress) for the treatment of Raynaud's phenomenon (RP) was assessed by patient diary data and by… 
1982
1982
Insulin releasing action of 2-[2-(4,5-dihydro-1H-imadazol-2-yl)-1-phenylethyl] pyridine dihydrochloride sesquihydrate (DG-5128), a new, orally effective hypoglycaemic agent.
2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenylethyl] pyridine dihydrochloride sesquilhydrate (DG-5128) is a new orally effective… 
1980
1980
Metabolic Effects of Chronic Prazosin Treatment
The effects of chronic (3 mg/day for 1 week) administration of the vasodilator drug prazosin on several metabolic and endocrine… 
1979
1979
Effects of Prazosin and Phentolamine on Arterial Pressure, Heart Rate, and Renin Activity: Evidence in the Conscious Rat for the Functional Significance of the Presynaptic α-Receptor
We examined the funetional significance of the presynaptic alphaadrenergic receptor, inhibitory to stimulus-induced… 
1979
1979
Comparative Effects of Prazosin and Phenoxybenzamine on Arterial Blood Pressure, Heart Rate, and Plasma Catecholamines in Essential Hypertension
Summary We investigated the possibility that selective blockade of postjunctional α-adrenergic receptors results in an enhanced… 
Highly Cited
1977
Highly Cited
1977
Synthesis and identification of the major metabolites of prazosin formed in dog and rat.
The 6-O-demethyl and 7-O-demethyl analogues of the new antihypertensive drug prazosin [2-[4-(2-furoyl)-piperazin-1-yl]-4-amino-6… 
1977
1977
Mechanism of the hypotensive action of prazosin.
The mechanism of action of prazosin was studied in anesthetized rats by comparison with the peripherally-acting anti-hypertensive… 
1975
1975
The clinical evaluation of prazosin, a new antihypertensive agent.
: The hemodynamic and therapeutic profiles of prazosin have been delineated in a comprehensive clinical program involving more…