• Publications
  • Influence
2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology.
TLDR
The If Inhibitor Ivabradine in Patients With Coronary Artery Disease and Left Ventricular Dysfunction is evaluated as well as patients with Diabetes mellitus for Optimal management of Multivessel disease.
Heart Physiology: From Cell to Circulation
  • L. Opie
  • Medicine, Biology
  • 1 December 2003
TLDR
A Basic Cardiovascular Physiology Introductory cardiovascular concepts Control of the circulation Heart cells and organelles, and Pathophysiology Lack of blood flow: Ischemia and angina Acute coronary syndromes.
Editor's introduction
  • L. Opie
  • Cardiovascular Drugs and Therapy
  • 2004
I schemic heart disease remains a most common illness and a leading cause of death. The purpose of this issue is to delineate currently accepted concepts for the management of transient myocardial
Hypertension in Sub-Saharan African Populations
TLDR
Differences from whites in etiology and therapeutic responses in sub-Saharan African populations are graded and overlapping rather than absolute, and two lifestyle changes that are feasible and should help to stem the epidemic of hypertension in Africa are a decreased salt intake and decreased obesity.
Controversies in ventricular remodelling
Ventricular remodelling describes structural changes in the left ventricle in response to chronic alterations in loading conditions, with three major patterns: concentric remodelling, when a pressure
Metabolic mechanisms in heart failure.
TLDR
The cellular mechanisms and pathophysiology of altered metabolism and insulin resistance in heart failure, and appropriate therapies to mitigate aberrant metabolism include intense neurohumoral antagonism, limitation of diuretics, correction of hypokalemia, exercise, and diet are reviewed.
Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway.
TLDR
The protective effect of the SAFE pathway is shown in IPostC, with the activation of TNFalpha, its receptor type 2, and STAT-3, which is activated independently of the well-known Reperfusion Injury Salvage Kinases (RISK) pathway, which involves the kinases Akt and Erk1/2.
Corrigendum to: ‘2013 ESC guidelines on the management of stable coronary artery disease’
[Eur Heart J (2013);34:2949–3003; doi:10.1093/eurheartj/eht296]. In the legends for Figures 6 and 7, the amount of fractional flow reserve should read ‘< 0.80’ instead of ‘=0.80.’ There was also …
The red wine hypothesis: from concepts to protective signalling molecules.
TLDR
Evidence for and against the 'red wine hypothesis', whereby red wine is more likely to confer cardiovascular benefits than white wine are reviewed, and Mechanistic feasibility strengthens the case for prospective therapeutic trials of alcohol vs. red wine vs. resveratrol.
...
1
2
3
4
5
...