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Diabetes, oxidative stress and therapeutic strategies.
TLDR
It appears important to develop new compounds that target key vascular ROS producing enzymes and mimic endogenous antioxidants, which might prove clinically relevant in preventing the development and/or retarding the progression of diabetes associated with vascular diseases. Expand
Identification of a novel role for sphingolipid signaling in TNF alpha and ischemic preconditioning mediated cardioprotection.
TLDR
TNF alpha activates preconditioning-like tolerance against infarction and contractile dysfunction and this cardioprotection is mediated, in part, via activation of novel sphingolipid signaling intermediates. Expand
Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: possible therapeutic targets?
TLDR
It appears that both a lack and excess of NO production in diseases can have various important pathological implications, and NOS modulators (exogenous and endogenous) and their therapeutic effects are discussed. Expand
Direct and indirect antioxidant properties of α-lipoic acid and therapeutic potential.
TLDR
Dietary supplementation with α-lipoic acid has been successfully employed in a variety of in vivo models of disease associated with an imbalance of redox status: diabetes and cardiovascular diseases. Expand
Antioxidant Properties of an Endogenous Thiol: Alpha-lipoic Acid, Useful in the Prevention of Cardiovascular Diseases
TLDR
More mechanistic and human in vivo studies are needed to determine whether optimizing the dietary intake of ALA can help to decrease cardiovascular diseases and a more complete understanding of cellular biochemical events that influence oxidative damage is required. Expand
Distribution of tyrosine hydroxylase, dopamine, and serotonin in the central nervous system of amphioxus (Branchiostoma lanceolatum): Implications for the evolution of catecholamine systems in
TLDR
It is concluded that the noradrenergic system is probably an innovation of vertebrates that appeared along with the neural crest and specific hindbrain nuclei and could be an ancestral character of chordates. Expand
Anthracyclines/trastuzumab: new aspects of cardiotoxicity and molecular mechanisms.
TLDR
Trastuzumab (TRZ), a humanized anti-HER2 monoclonal antibody, is currently recommended as first-line treatment for patients with metastatic HER2(+) tumors, but the use of TRZ may be limited by the development of drug intolerance, such as cardiac dysfunction. Expand
Carbon monoxide: mechanisms of action and potential clinical implications.
TLDR
The development of a technology concerning CO-RMs that controls the delivery and action of CO under different pathological conditions represents a major step forward in the development of CO-based pharmaceuticals with therapeutic applications. Expand
Studies by electron paramagnetic resonance of the importance of iron in the hydroxyl scavenging properties of ascorbic acid in plasma: Effects of iron chelators
TLDR
It was demonstrated that plasma AFR remains constant after rat feeding with vitamin C, and AFR, which is naturally present in plasma, could be used as an index of oxidative stress in which free radicals or adverse iron mobilisation are implicated. Expand
Dopamine and norepinephrine turnover in various regions of the rat brain after chronic manganese chloride administration.
TLDR
The results which show that chronic administration of manganese may cause regionally different changes in catecholamine turnover were discussed in relation to the accumulation ofManganese in the brain regions and to other metabolic changes associated with Manganese toxicity. Expand
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