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Dopamine receptors: from structure to function.
Target deletion of several of these dopamine receptor genes in mice should provide valuable information about their physiological functions and provide unequivocal evidence for the involvement of one of these receptors in the etiology of various central nervous system disorders. Expand
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
In homozygote mice, dopamine persists at least 100 times longer in the extracellular space, explaining the biochemical basis of the hyperdopaminergic phenotype and demonstrating the critical role of the transporter in regulating neurotransmission. Expand
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
It is demonstrated that, apart from its classical function in receptor desensitization, beta-arrestin 2 also acts as a signaling intermediate through a kinase/phosphatase scaffold, thus implicating beta-arsenin 2 as a positive mediator of dopaminergic synaptic transmission and a potential pharmacological target for dopamine-related psychiatric disorders. Expand
Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade.
The involvement of GSK-3 as an important mediator of DA and lithium action in vivo is supported and modulation of the Akt/GSK-3 pathway might be relevant to DA-related disorders, such as attention deficit hyperactivity disorder and schizophrenia. Expand
Plasma membrane monoamine transporters: structure, regulation and function
The classical biogenic amine neurotransmitters — dopamine, noradrenaline, and 5-hydroxytryptamine — control a variety of functions including locomotion, autonomic function, hormone secretion, and theExpand
Mice with Reduced NMDA Receptor Expression Display Behaviors Related to Schizophrenia
The generation of mice expressing only 5% of normal levels of the essential NMDAR1 (NR1) subunit is reported, supporting a model in which reduced NMDA receptor activity results in schizophrenic-like behavior and reveals how pharmacological manipulation of monoaminergic pathways can affect this phenotype. Expand
Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity.
The parallels between the DAT knockout mice and individuals with ADHD suggest that common mechanisms may underlie some of their behaviors and responses to psychostimulants. Expand
Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.
Data suggest that beta-arrestin binding, which terminates receptor-G protein coupling, also initiates a second wave of signal transduction in which the "desensitized" receptor functions as a critical structural component of a mitogenic signaling complex. Expand
Desensitization of G protein-coupled receptors and neuronal functions.
An important and specific role of GRKs and beta arrestins in regulating physiological responsiveness to psychostimulants and morphine suggests potential involvement of these molecules in certain brain disorders, such as addiction, Parkinson's disease, mood disorders, and schizophrenia. Expand
Tryptophan Hydroxylase-2 Controls Brain Serotonin Synthesis
This work reports a functional (C1473G) single-nucleotide polymorphism in mouse Tph2 that results in the substitution of Pro447 with Arg447 and leads to decreased serotonin levels in PC12 cells, providing direct evidence for a fundamental role of Tph1 in brain serotonin synthesis. Expand