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Putative Transport Mechanism and Intracellular Fate of Trans-1-Amino-3-18F-Fluorocyclobutanecarboxylic Acid in Human Prostate Cancer
TLDR
A possible mechanism of anti–18F-FACBC PET for prostate cancer is suggested, indicating that Na+-dependent transporters are mainly responsible for the uptake of this tracer. Expand
The citrus flavonoids hesperetin and naringenin block the lipolytic actions of TNF-alpha in mouse adipocytes.
TLDR
It is shown that hesperetin and naringenin, two citrus flavonoids, inhibit TNF-alpha-stimulated FFA secretion from mouse adipocytes, and these findings may be useful for ameliorating FFA-induced insulin resistance. Expand
Cerebral blood flow abnormalities induced by transient hypothyroidism after thyroidectomy —analysis by Tc-99m-HMPAO and SPM96—
TLDR
A significant rCBF decrease in the parietal lobe and part of the occipital lobe in patients with induced transient hypothyroidism after thyroidectomy is demonstrated, which might contribute to understanding of the depressive state. Expand
Transport mechanisms of hepatic uptake and bile excretion in clinical hepatobiliary scintigraphy with 99mTc-N-pyridoxyl-5-methyltryptophan.
TLDR
Investigating the transport mechanisms of human hepatic uptake and bile excretion in hepatobiliary scintigraphy with (99m)Tc-PMT found it may be a useful ligand as a noninvasive method of visualizing and quantifying hepatOBiliary transporter functionality, which could predict drug pharmacokinetics. Expand
Down‐regulation of calcium/calmodulin‐dependent protein kinase kinase 2 by androgen deprivation induces castration‐resistant prostate cancer
Conversion into androgen‐hypersensitive state and adaptation to the low concentration of androgen during ADT cause relapse of prostate cancer (PCa). It is important to identify differentiallyExpand
The usefulness of 18F-FDG PET/MRI fusion image in diagnosing pancreatic tumor: comparison with 18F-FDG PET/CT
TLDR
FDG-PET/MRI fusion image was useful in differentiating pancreatic cancer from benign lesions and helpful in evaluating relationship between lesions and surrounding tissues as well as in detecting extra benign cysts. Expand
Radioiodinated VEGF to image tumor angiogenesis in a LS180 tumor xenograft model.
TLDR
Radioiodinated VEGF(121) is a promising tracer for noninvasive delineation of angiogenesis in vivo and is correlated with degree of tumor vascularity. Expand
Usefulness of rCBF analysis in diagnosing Parkinson’s disease: supplemental role with MIBG myocardial scintigraphy
TLDR
In the differential diagnosis between PD and PS, although its usefulness might be limited, analysis of rCBF in the occipital lobe added to 123I-MIBG myocardial imaging can be recommended. Expand
The reproducibility of deep-inspiration breath-hold 18F-FDG PET/CT technique in diagnosing various cancers affected by respiratory motion
TLDR
Although the CV value of SUVmax with DibH technique is better in thoracic lesions compared with that in abdominal lesions, the reproducibility was acceptable and the DIBH technique improves the inaccurate quantification of both SUVmax and MV. Expand
A strategy for the study of cerebral amino acid transport using iodine-123-labeled amino acid radiopharmaceutical: 3-iodo-alpha-methyl-L-tyrosine.
TLDR
123I-L-AMT appears to be a useful radiopharmaceutical for the selective measurement of cerebral amino acid transport, both operating across the blood-brain barrier and cell membranes of the brain. Expand
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