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pyripyropene A

Known as: FO 1289A 
National Institutes of Health

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PyridinesSesquiterpenes

Papers overview

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2018
2018
Determination of Penicillium griseofulvum-oriented pyripyropene A, a selective inhibitor of acyl-coenzyme A:cholesterol acyltransferase 2, in mouse plasma using liquid chromatography-tandem mass…
In this study, we developed a method for the determination of Penicillium griseofulvum-oriented pyripyropene A (PPPA), a… 
2018
2018
Insecticidal properties of pyripyropene A, a microbial secondary metabolite, against agricultural pests.
We previously reported the strong insecticidal activity of a microbial secondary metabolite, pyripyropene A (PP-A), against… 
2015
2015
New Pyripyropene A Derivatives, Highly SOAT2-Selective Inhibitors, Improve Hypercholesterolemia and Atherosclerosis in Atherogenic Mouse Models
Sterol O-acyltransferase 2 (SOAT2; also known as ACAT2) is considered as a new therapeutic target for the treatment or prevention… 
Review
2015
Review
2015
Acyltransferase inhibitors: a patent review (2010–present)
Introduction: Acyltransferase (AT) catalyzes the transfer of an acyl moiety from acyl-coenzyme A (acyl-CoA) to an acceptor. ATs… 
2014
2014
In vitro metabolism of pyripyropene A and ACAT inhibitory activity of its metabolites
Pyripyropene A (PPPA, 1) of fungal origin, a selective inhibitor of acyl-CoA:cholesterol acyltransferase 2 (ACAT2), proved orally… 
2008
2008
Penicillium griseofulvum F1959, high-production strain of pyripyropene a, specific inhibitor of acyl-CoA: cholesterol acyltransferase 2.
Acyl-coenzyme A: cholesterol acyltransferase (ACAT) catalyzes cholesterol esterification and plays an important role in the… 
2008
2008
Selectivity of Pyripyropene Derivatives in Inhibition toward Acyl-CoA:cholesterol Acyltransferase 2 Isozyme
Selectivity of 96 semisynthetic derivatives prepared from fungal pyripyropene A, originally isolated as a potent inhibitor of… 
2005
2005
Exploiting PdII and TiIII chemistry to obtain gamma-dioxygenated terpenoids: synthesis of rostratone and novel approaches to aphidicolin and pyripyropene A.
In nature there are several terpenoids with a characteristic gamma-dioxygenated system on the A ring, and many of them show… 
2003
2003
Mass-production of human ACAT-1 and ACAT-2 to screen isoform-specific inhibitor: a different substrate specificity and inhibitory regulation.
2001
2001
Convergent synthesis of arisugacin skeletons and their acetylcholinesterase inhibitory activity.
In the course of our screening of microbial metabolites that inhibit the activity of acetylcholinesterase (AchE), we isolated… 
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