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pyripyropene A

Known as: FO 1289A 
National Institutes of Health

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2 relations

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PyridinesSesquiterpenes

Papers overview

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2018
2018
Determination of Penicillium griseofulvum-oriented pyripyropene A, a selective inhibitor of acyl-coenzyme A:cholesterol acyltransferase 2, in mouse plasma using liquid chromatography-tandem mass…
In this study, we developed a method for the determination of Penicillium griseofulvum-oriented pyripyropene A (PPPA), a… 
2017
2017
Identification of pyripyropene A as a promising insecticidal compound in a microbial metabolite screening
Approximately 300 microbial natural products in our library were screened for insecticidal activities against three species of… 
2016
2016
Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2).
A series of pyripyropene A-based compounds were designed and synthesized by opening the upper section of the A-ring, which… 
2015
2015
New Pyripyropene A Derivatives, Highly SOAT2-Selective Inhibitors, Improve Hypercholesterolemia and Atherosclerosis in Atherogenic Mouse Models
Sterol O-acyltransferase 2 (SOAT2; also known as ACAT2) is considered as a new therapeutic target for the treatment or prevention… 
2014
2014
In vitro metabolism of pyripyropene A and ACAT inhibitory activity of its metabolites
Pyripyropene A (PPPA, 1) of fungal origin, a selective inhibitor of acyl-CoA:cholesterol acyltransferase 2 (ACAT2), proved orally… 
2013
2013
Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 3.
2008
2008
Penicillium griseofulvum F1959, high-production strain of pyripyropene a, specific inhibitor of acyl-CoA: cholesterol acyltransferase 2.
Acyl-coenzyme A: cholesterol acyltransferase (ACAT) catalyzes cholesterol esterification and plays an important role in the… 
Highly Cited
2007
Highly Cited
2007
Selectivity of Microbial Acyl-CoA : cholesterol Acyltransferase Inhibitors toward Isozymes
The selectivity of microbial inhibitors of acyl-CoA : cholesterol acyltransferase (ACAT) toward the two isozymes, ACAT1 and ACAT2… 
2005
2005
Exploiting PdII and TiIII chemistry to obtain gamma-dioxygenated terpenoids: synthesis of rostratone and novel approaches to aphidicolin and pyripyropene A.
In nature there are several terpenoids with a characteristic gamma-dioxygenated system on the A ring, and many of them show… 
2003
2003
Mass-production of human ACAT-1 and ACAT-2 to screen isoform-specific inhibitor: a different substrate specificity and inhibitory regulation.
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