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Biflavonoids from Torreya nucifera displaying SARS-CoV 3CLpro inhibition
More potent activity appeared to be associated with the presence of an apigenin moiety at position C-3′ of flavones, as biflavone had an effect on 3CLpro inhibitory activity. Expand
SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii
All quinone-methide triterpenes 1–4 have proven to be competitive by the kinetic analysis and show potent inhibitory activities in A-ring and more hydrophobic E-ring assist to exhibit potent activity. Expand
In vitro antiviral activity of phlorotannins isolated from Ecklonia cava against porcine epidemic diarrhea coronavirus infection and hemagglutination
Results suggest that compounds isolated from E. cava have strong antiviral activity against PEDV, inhibiting viral entry and/or viral replication, and may be developed into natural therapeutic drugs against coronavirus infection. Expand
Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities.
Five flavonols were isolated from Rhodiola rosea, and compared with commercially available flavonoids to facilitate analysis of their structure-activity relationship (SAR), and gossypetin exhibited the most potent inhibitory activity, with IC(50) values of 0.8 to 56.9 microM. Expand
Inhibition of neuraminidase activity by polyphenol compounds isolated from the roots of Glycyrrhiza uralensis.
  • Y. Ryu, J. Kim, +5 authors W. Lee
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 1 February 2010
Structural-activity analysis showed that the furan rings of the polyphenols were essential for neuraminidase inhibitory activity, and that this activity was enhanced by the apioside group on the chalcone and flavanone backbone. Expand
Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation.
Overall, several flavonoids from P. corylifolia might be useful remedies for treating inflammatory diseases by inhibiting IL-6-induced STAT3 activation and phosphorylation. Expand
Characteristic of alkylated chalcones from Angelica keiskei on influenza virus neuraminidase inhibition.
As part of the ongoing effort to develop influenza virus neuraminidase (NA) inhibitors from various medicinal plants, bioassay-guided fractionation to isolated six alkylated chalcones from Angelica keiskei emerged as new compound containing the rare alkyl substitution. Expand
Salvia plebeia extract inhibits the inflammatory response in human rheumatoid synovial fibroblasts and a murine model of arthritis.
Results indicate thatSPE is therapeutically efficacious against chronic inflammatory arthritis, suggesting that SPE is a candidate for treating RA. Expand
Inhibition of LFA-1/ICAM-1-mediated cell adhesion by stilbene derivatives from Rheum undulatum
Six stilbenes from Rheum undulatum rhizomes are good candidates for therapeutic strategies towards inflammation and had an inhibitory effect on direct binding between sVCAM-1 and VLA-4 of THP-1 cells. Expand
Purification and functional characterization of the first stilbene glucoside-specific β-glucosidase isolated from Lactobacillus kimchi.
Stilbene glucoside-specific β-glucosidase is the first enzyme isolated from lactic acid bacteria capable of bio-converting various stilbenes glucosides into stilBene. Expand