Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase)
- H. Miyadera, K. Shiomi, S. Ōmura
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 6 January 2003
Atpenins potently and specifically inhibit the succinate-ubiquinone reductase activity of mitochondrial complex II, suggesting that atpenins may be useful tools for clarifying the biochemical and structural properties ofcomplex II, as well as for determining its physiological roles in mammalian tissues.
In vitro and in vivo antimalarial activities of a non-glycosidic 18-membered macrolide antibiotic, borrelidin, against drug-resistant strains of Plasmodia.
The antimalarial profile of borrelidin is reported here, a known nonglycosidic 18-membered macrolide antibiotic with a cyclopentanecarboxylic acid side chain, in comparison with those of clinically used antimalaria drugs.
Lariatins, Novel Anti-mycobacterial Peptides with a Lasso Structure, Produced by Rhodococcus jostii K01-B0171
Two anti-mycobacterial peptides with a lasso structure, named lariatins A and B, were separated by HP-20 and ODS column chromatographies and purified by HPLC from the culture broth of Rhodococcus…
Constitutively Activated ALK2 and Increased SMAD1/5 Cooperatively Induce Bone Morphogenetic Protein Signaling in Fibrodysplasia Ossificans Progressiva*
The findings suggest that the heterotopic bone formation in FOP may be induced by a constitutively activated BMP receptor signaling through Smad1 or Smad5, andGene transfer of Smad7 or inhibition of type I receptors with dorsomorphin may represent strategies for blocking the activity induced by ALK2(R206H) in Fop.
Molecular cloning of the gene cluster for lariatin biosynthesis of Rhodococcus jostii K01-B0171
- J. Inokoshi, Maki Matsuhama, Midori Miyake, H. Ikeda, H. Tomoda
- BiologyApplied Microbiology and Biotechnology
- 3 March 2012
The biosynthetic gene cluster for lariatins A and B, anti-mycobacterial peptide antibiotics with a unique “lasso” structure, was cloned from Gram-positive bacterium Rhodococcus jostii K01-B0171 and it was proposed that the linear precursor LarA is processed by LarB, LarC, and LarD, and the mature lariatin is exported by LarE.
Pyripyropenes, highly potent inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus.
The continuous search has led to the discovery of highly potent ACATinhibitors termed pyripyropene produced by Aspergillus fumigatus FO-1289, and the production, isolation and somebiochemical and biological activities of these compounds are described.
Mechanism of action of cerulenin on fatty acid synthetase. Effect of cerulenin on iodoacetamide-induced malonyl-CoA decarboxylase activity.
Results indicated that the reaction of cerulenin with the peripheral SH-groups of the synthetase is responsible for the inactivation.
Cyslabdan, a New Potentiator of Imipenem Activity against Methicillin-resistant Staphylococcus aureus, Produced by Streptomyces sp. K04-0144
The structure of cyslabdan was elucidated by spectroscopic analyses including NMR, which showed that the compound has a labdane-type diterpene skeleton connecting with an N-acetylcysteine via thioether linkage.
New rugulosins, anti-MRSA antibiotics, produced by Penicillium radicum FKI-3765-2.
Rugulosin A to C showed antimicrobial activity against methicillin-resistant Staphylococcus aureus and new rugulosins B and C were a homodimer of the same anthraquinone moieties.
ACAT2 Is Localized to Hepatocytes and Is the Major Cholesterol-Esterifying Enzyme in Human Liver
The data suggest that in diseases in which dysregulation of cholesterol metabolism occurs, such as hypercholesterolemia and atherosclerosis, ACAT2 should be considered a target for prevention and treatment.